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0SSR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSSTR1
DescriptionSomatostatin receptor type 1 (ss1r) (srif-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004994 somatostatin receptor activity (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0007267 cell-cell signaling (TAS)
0007586 digestion (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0008285 negative regulation of cell proliferation (TAS)
0007584 response to nutrients (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Somatostatin is a neurotransmitter/hormone with a wide range of biologialfunctions . It has an important role in the neuroendocrine system andinhibits secretion of growth hormone and prolactin in the anteriorpituitary. It also inhibits secretion in the intestine (including gastricacid in the stomach).ancreatic acinar cells and pancreatic beta-cells.timulates absorption in the intestine and modulates smooth musclecontractility. In the CNS.t is a neurotransmitter activating a hyperpolarising K+ current and inhibiting Ca2+ influx.nd is believed toplay important roles in regulating locomotor activity and cognitivefunction. Receptor subtypes were originally proposed on the basis offunctional and radio-ligand binding studies.nd cloning has now confirmedthe presence of at least 4 subtypes.
  IPR000586:Somatostatin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Somatostatin is a neurotransmitter/hormone with a wide range of biologialfunctions . It has an important role in the neuroendocrine system andinhibits secretion of growth hormone and prolactin in the anteriorpituitary. It also inhibits secretion in the intestine (including gastricacid in the stomach).ancreatic acinar cells and pancreatic beta-cells.timulates absorption in the intestine and modulates smooth musclecontractility. In the CNS.t is a neurotransmitter activating a hyperpolarising K+ current and inhibiting Ca2+ influx.nd is believed toplay important roles in regulating locomotor activity and cognitivefunction. Receptor subtypes were originally proposed on the basis offunctional and radio-ligand binding studies.nd cloning has now confirmedthe presence of at least 4 subtypes.High levels of mRNA for human SS1 receptors have been found in the jejunumand stomach.ith lower levels in the pancreas.olon and kidney - mRNA isabsent in the brain. Conversely.n rodent tissue.igh levels of mRNAare found in the brain.ut are absent in peripheral tissues. Thebinding of agonists to recombinant receptor expressed in CHO cells is notregulated by GTP and is unaffected by pertussis toxin .
  IPR001116:Somatostatin receptor, type 1
IPR000276:7tm_1 
Evalue:-96.4685211181641 
Location:75-323IPR001116:SOMATOSTTN1R 
Evalue:0 
Location:340-360IPR001116:SOMATOSTTN1R 
Evalue:0 
Location:37-56IPR001116:SOMATOSTTN1R 
Evalue:0 
Location:17-36IPR001116:SOMATOSTTN1R 
Evalue:0 
Location:361-380IPR000586:SOMATOSTATNR 
Evalue:0 
Location:325-337IPR000586:SOMATOSTATNR 
Evalue:0 
Location:57-69
SequencesProtein: SSR1_HUMAN (391 aa)
mRNA: NM_001049
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentK04217
  Level 3 annotation:
    somatostatin receptor 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 36 residues, 37746954-37747060Exon2: 57 residues, 37747398-37747565Exon3: 1341 residues, 37748001-37752019Exon4: 2 residues, -Jump to SSR1_HUMAN  
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