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0SSDH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDH5A1
DescriptionSuccinate semialdehyde dehydrogenase, mitochondrial precursor (ec 1.2.1.24) (nad(+)-dependent succinic semialdehyde dehydrogenase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (ISS)
0005489 electron transporter activity (TAS)
0004777 succinate-semialdehyde dehydrogenase activity (TAS)
0009450 gamma-aminobutyric acid catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3.
  IPR002086:Aldehyde dehydrogenase
Succinic semialdehyde dehydrogenase is one of three enzymes constituting 4-aminobutyrate (GABA) degradation in both prokaryotes and eukaryotes.atalysing the (NAD(P)+)-dependent catabolism reaction of succinic semialdehyde to succinate for metabolism by the citric acid cycle. In Escherichia coli.uccinic semialdehyde dehydrogenase is located in a unidirectionally transcribed gene cluster encoding enzymes for GABA degradation and is suggested to be co-transcribed with succinic semialdehyde transaminase from a common promoter upstream of SSADH . Similar gene arrangements can be found in characterised Ralstonia eutropha and the genome analysis of Bacillus subtilis. Prokaryotic succinic semialdehyde dehydrogenases () share high sequence homology to characterised succinic semialdehyde dehydrogenases from rat and human ().xhibiting conservation of proposed cofactor binding residues.nd putative active sites (G-237 and G-242.-293 and G-259 respectively of rat SSADH) . Eukaryotic SSADH enzymes exclusively utilise NAD+ as a cofactor.xhibiting little to no NADP+ activity . While a NADP+ preference has been detected in prokaryotes in addition to both NADP+- and NAD+-dependencies as in Escherichia coli.seudomonas.nd Klebsiella pneumoniae . The function of this alternative SSADH currently is unknown.ut has been suggested to play a possible role in 4-hydroxyphenylacetic degradation . SSADH enzyme belongs to the aldehyde dehydrogenase family.haring a common evolutionary origin and enzymatic mechanism with lactaldehyde dehydrogenase . Like in lactaldehyde dehydrogenase and succinate semialdehyde dehydrogenase.he mammalian catalytic glutamic acid and cysteine residues are conserved in all the enzymes of this family.
  IPR010102:Succinic semialdehyde dehydrogenase
Aldehyde dehydrogenases ( and ) are enzymes which oxidizea wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least fourdifferent forms of the enzyme are known : class-1 (or Ald C) a tetramericcytosolic enzyme.lass-2 (or Ald M) a tetrameric mitochondrial enzyme.lass-3 (or Ald D) a dimeric cytosolic enzyme.nd class IV a microsomal enzyme.Aldehyde dehydrogenases have also been sequenced from fungal and bacterialspecies. A number of enzymes are known to be evolutionary related to aldehydedehydrogenases.A glutamic acid and a cysteine residue have been implicated in the catalyticactivity of mammalian aldehyde dehydrogenase. These residues are conserved inall the enzymes of this family.
  IPR012303:NAD-dependent aldehyde dehydrogenase
IPR002086:Aldedh 
Evalue:-214.568634033203 
Location:69-530
SequencesProtein: SSDH_HUMAN (535 aa)
mRNA: NM_001080 NM_170740
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00139
  Level 3 annotation:
    succinate-semialdehyde dehydrogenase
  Level 2 annotation:
    Butanoate metabolism
    Glutamate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 128 residues, 24603175-24603557Exon2: 30 residues, 24610729-24610813Exon3: 59 residues, 24611469-24611640Exon4: 41 residues, 24613075-24613192Exon5: 15 residues, 24620036-24620075Exon6: 50 residues, 24623373-24623517Exon7: 50 residues, 24628607-24628751Exon8: 55 residues, 24630973-24631132Exon9: 58 residues, 24636203-24636373Exon10: 21 residues, 24640325-24640384Exon11: 1235 residues, 24641713-24645413Exon12: 2 residues, -Jump to SSDH_HUMANExon1: 128 residues, 24603175-24603557Exon2: 30 residues, 24610729-24610813Exon3: 59 residues, 24611469-24611640Exon4: 41 residues, 24613075-24613192Exon5: 50 residues, 24623373-24623517Exon6: 50 residues, 24628607-24628751Exon7: 55 residues, 24630973-24631132Exon8: 58 residues, 24636203-24636373Exon9: 21 residues, 24640325-24640384Exon10: 1235 residues, 24641713-24645413Exon11: 2 residues, -Jump to SSDH_HUMAN  
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