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0SRP68_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSRP68
DescriptionSignal recognition particle 68 kda protein (srp68).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005730 nucleolus (TAS)
0005840 ribosome (TAS)
0005786 signal recognition particle (sensu Eukaryota) (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the tetratricopeptide repeat (TPR) (found in kinesin light chains.NAP regulatory proteins.lathrin heavy chains and bacterial aspartyl-phosphate phosphatases).nd the pentatricopeptide repeat (PPR) (RNA-processing proteins). The TRP is likely to be an ancient repeat.ince it is found in eukaryotes.acteria and archaea.hereas the PPR repeat is found predominantly in higher plants. The superhelix formed from these repeats can bind ligands at a number of different regions.nd has the ability to acquire multiple functional roles .
  IPR011990:Tetratricopeptide-like helical
IPR011990:TPR-like_helical 
Evalue:0 
Location:153-515
SequencesProtein: SRP68_HUMAN (627 aa)
mRNA: NM_014230
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03107
  Level 3 annotation:
    signal recognition particle, subunit SRP68
  Level 2 annotation:
    Protein export
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 275 residues, 71546785-71547609Exon2: 20 residues, 71548094-71548150Exon3: 27 residues, 71548578-71548654Exon4: 45 residues, 71551504-71551634Exon5: 33 residues, 71552967-71553062Exon6: 54 residues, 71553713-71553870Exon7: 23 residues, 71555581-71555646Exon8: 35 residues, 71558103-71558202Exon9: 49 residues, 71565078-71565219Exon10: 29 residues, 71567983-71568066Exon11: 38 residues, 71568785-71568895Exon12: 29 residues, 71569167-71569250Exon13: 67 residues, 71571651-71571847Exon14: 40 residues, 71574892-71575006Exon15: 24 residues, 71578053-71578120Exon16: 75 residues, 71579983-71580202Exon17: 2 residues, -Jump to SRP68_HUMAN  
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Loci Cluster (Details)Loci: 3038 70178864-70255068 ~-76K 16552(+)Loci: 3039 70256378-70277089 ~-21K 16559(SLC9A3R1)(+)Loci: 4310 70349762-70367602 ~-18K 16565(GRIN2C)(-)Loci: 4311 70370220-70380710 ~-10K 16567(FDXR)(-)Loci: 4312 70546549-70554669 ~-8K 16577(ATP5H)(-)Loci: 4313 70637918-70639472 ~-2K 16582(NT5C)(-)Loci: 4314 70744289-70769272 ~-25K 16589(GGA3)(-)Loci: 4315 70780668-70797109 ~-16K 16594(SLC25A19)(-)Loci: 4316 71265612-71272875 ~-7K 16620(GALK1)(-)Loci: 4317 71514521-71534972 ~-20K 16639(EVPL)(-)Loci: 4318 71546785-71580202 ~-33K 16642(SRP68)(-)Loci: 3040 71582486-71585168 ~-3K 16644(GALR2)(+)Loci: 3041 71586857-71590480 ~-4K 16645(+)Loci: 4319 71588681-71611451 ~-23K 16647(EXOC7)(-)Loci: 3037 69833964-69859062 ~-25K 16537(+)Link out to UCSC