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0SRGP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSlit-robo rho gtpase activating protein 1 (srgap1) (rho-gtpase- activating protein 13).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain was first identified in cell division control protein 15 fromfission yeast where after the onset of mitosis.t forms a ring-like structurewhich co-localizes with the medial actin ring. It may mediate cytoskeletalrearrangements required for cytokinesis. Also occurs in protein-tyrosine it may play a rolein regulatory processes such as cell cycle control.nd in human Rho-GAPhematopoietic protein it has an inhibitory effect on stress fiberorganisation.
Members of the Rho family of small G proteins transduce signals from plasma-membranereceptors and control cell adhesion.otility and shape by actin cytoskeleton formation.Like all other GTPases.ho proteins act as molecular switches.ith an activeGTP-bound form and an inactive GDP-bound form. The active conformation is promoted byguanine-nucleotide exchange factors.nd the inactive state by GTPase-activating proteins(GAPs) which stimulate the intrinsic GTPase activity of small G proteins.This entry is a Rho/Rac/Cdc42-like GAP domain.hat is found in a wide variety of large.ulti-functional proteins .A number of structure are known for this family .The domain is composed of seven alpha helices.This domain is also known as the breakpoint cluster region-homology (BH) domain.
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to and/or Cdc42.nactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008936:Rho GTPase activation protein
SequencesProtein: SRGP1_HUMAN (1085 aa)
mRNA: NM_020762
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK07526
  Level 3 annotation:
    SLIT-ROBO Rho GTPase activating protein
  Level 2 annotation:
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 42 residues, 62524807-62524930Exon2: 67 residues, 62663993-62664189Exon3: 56 residues, 62669956-62670119Exon4: 23 residues, 62696996-62697059Exon5: 63 residues, 62722836-62723019Exon6: 45 residues, 62723493-62723622Exon7: 76 residues, 62742963-62743185Exon8: 36 residues, 62745164-62745266Exon9: 68 residues, 62758965-62759163Exon10: 30 residues, 62760332-62760417Exon11: 11 residues, 62767045-62767073Exon12: 36 residues, 62771322-62771425Exon13: 22 residues, 62774978-62775039Exon14: 28 residues, 62775173-62775251Exon15: 47 residues, 62777287-62777422Exon16: 37 residues, 62788978-62789084Exon17: 77 residues, 62791808-62792033Exon18: 28 residues, 62795860-62795940Exon19: 62 residues, 62806023-62806204Exon20: 47 residues, 62807636-62807771Exon21: 115 residues, 62807907-62808247Exon22: 472 residues, 62822341-62823751Exon23: 22 residues, 62823767-62823827Exon24: 2 residues, -Jump to SRGP1_HUMAN  
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