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0SRBS1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSORBS1
DescriptionSorbin and sh3 domain-containing protein 1 (ponsin) (c-cbl-associated protein) (cap) (sh3 domain protein 5) (sh3p12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005924 cell-substrate adherens junction (ISS)
0045121 lipid raft (ISS)
0005634 nucleus (IDA)
0001725 stress fiber (ISS)
0005915 zonula adherens (TAS)
0003779 actin binding (TAS)
0005158 insulin receptor binding (IDA)
0048041 focal adhesion formation (ISS)
0015758 glucose transport (ISS)
0008286 insulin receptor signaling pathway (ISS)
0043149 stress fiber formation (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phagocytes form the first line of defence against invasion by micro-organisms. Engulfing of bacteria by neutrophils is accompanied by theconsumption of large amounts of oxygen - a so-called respiratory burst.Defects in phagocytosis involving the lack of a respiratory burst giverise to chronic granulomatous disease (CGD).n which patients are pre-disposed to infection.ften from otherwise non-pathogenic bacteria .Regulation of the respiratory burst takes place at the phagocytic vacuole.The process is mediated by NADPH oxidase.hich transports electrons acrossthe plasma membrane to form superoxide (an oxygen molecule with an extraelectron that is toxic to normal cells) in the vacuole interior. Theelectrons are carried across the membrane by a short electron transportchain in the form of an unusual flavocytochrome b .To conserve NADPH and avoid the toxic effects of superoxide.he oxidase remains inactive until it receives an appropriate stimulus. Activationinvolves the participation of a number of cytosolic proteins.ome of which attach to the flavocytochrome. P47phox.67phox and p40phox arespecialised components of phagocytic cells.ll of which contain SH3domains .y means of which they attach to proline-rich regions of otherproteins. Upon activation.47phox and p67phox are phosphorylated and.ith p40phox.ranslocate to the region of the plasma membrane formingthe phagocytic vacuole.here they associates with hydrophilic regionsof the flavocytochrome .
  IPR000108:Neutrophil cytosol factor 2
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
Sorbin is an active peptide present in the digestive tract.here it has pro-absorptive and anti-secretory effects in different parts of the intestine.ncluding the ability to decrease VIP (vasoactive intestinal peptide) and cholera toxin-induced secretion. It is expressed in some intestinal and pancreatic endocrine tumours in humans .Sorbin-homology domains are found in adaptor proteins such as vinexin.AP/ponsin and argBP2.hich regulate various cellular functions.ncluding cell adhesion.ytoskeletal organisation.nd growth factor signalling . In addition to the sorbin domain.hese proteins contain three SH3 (src homology 3) domains. The sorbin homology domain mediates the interaction of vinexin and CAP with flotillin.hich is crucial for the localisation of SH3-binding proteins to the lipid raft. region of the plasma membrane rich in cholesterol and sphingolipids that acts to concentrate certain signalling molecules. The sorbin homology domain of adaptor proteins may mediate interactions with the lipid raft that are crucial to intracellular communication .
  IPR003127:Sorbin-like
IPR003127:Sorb 
Evalue:-28.3098030090332 
Location:367-410IPR001452:SH3 
Evalue:-18.9208187539524 
Location:1234-1291IPR001452:SH3 
Evalue:-17.6382721639824 
Location:796-851IPR001452:SH3 
Evalue:-16.2518119729938 
Location:870-927IPR000108:P67PHOX 
Evalue:0 
Location:995-1012
SequencesProtein: SRBS1_HUMAN (1292 aa)
mRNA: NM_001034954
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK06086
  Level 3 annotation:
    sorbin and SH3 domain containing 1
  Level 2 annotation:
    Insulin signaling pathway
    Adherens junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1119 residues, 97061519-97064873Exon2: 39 residues, 97068066-97068179Exon3: 21 residues, 97071709-97071768Exon4: 260 residues, 97086267-97087041Exon5: 67 residues, 97088879-97089074Exon6: 44 residues, 97091031-97091157Exon7: 40 residues, 97091310-97091425Exon8: 17 residues, 97096152-97096199Exon9: 58 residues, 97100955-97101123Exon10: 30 residues, 97104628-97104714Exon11: 59 residues, 97107377-97107550Exon12: 18 residues, 97117396-97117446Exon13: 36 residues, 97121072-97121174Exon14: 24 residues, 97121730-97121796Exon15: 30 residues, 97125719-97125803Exon16: 40 residues, 97131431-97131546Exon17: 45 residues, 97133731-97133861Exon18: 18 residues, 97133984-97134032Exon19: 23 residues, 97144357-97144420Exon20: 27 residues, 97144747-97144822Exon21: 23 residues, 97146966-97147030Exon22: 59 residues, 97148763-97148936Exon23: 12 residues, 97155864-97155894Exon24: 50 residues, 97160379-97160524Exon25: 125 residues, 97164240-97164609Exon26: 39 residues, 97171707-97171820Exon27: 11 residues, 97171936-97171963Exon28: 45 residues, 97182194-97182323Exon29: 34 residues, 97184368-97184464Exon30: 24 residues, 97187236-97187302Exon31: 20 residues, 97190872-97190927Exon32: 2 residues, -Jump to SRBS1_HUMAN  
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Loci Cluster (Details)Loci: 3911 97355676-97406557 ~-51K 5399(ALDH18A1)(-)Loci: 3910 97061519-97190927 ~-129K 5391(SORBS1)(-)Link out to UCSC