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0SRBP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSREBF1
DescriptionSterol regulatory element binding protein 1 (srebp-1) (sterol regulatory element-binding transcription factor 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005789 endoplasmic reticulum membrane (TAS)
0005635 nuclear membrane (TAS)
0003702 RNA polymerase II transcription factor acti... (TAS)
0003700 transcription factor activity (NAS)
0006629 lipid metabolism (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundleof four helices in a left-handed twist with two crossover connections. TheHLH domain directs dimerisation.nd is juxtaposed to basic regions tocreate a DNA interaction interface surface that recognises specific DNAsequences. Basic region/HLH (bHLH) proteins regulate diverse biologicalpathways . bHLH proteins include MyoD .REBPs (sterol regulatory element binding proteins).nd yeast Pho4 (phosphatase system) .In certain proteins the bHLH domain contains a leucine-zipper motif. ThebHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a networkof proteins and determines sequence-specific DNA binding . bHLHZip domains occur in the transcription factors Myc.ad.ax and Usf . This entry is bHLHZip.hich covers the bHLH domain and the leucine zipper motif.hen present.
  IPR011598:Helix-loop-helix DNA-binding
Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation . They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development . The bHLH proteins can be classified into discrete categories. One such subdivision according to dimerisation.NA binding and expression characteristics defines seven groups . Class I proteins form dimers within the group or with class II proteins. Class II can only form heterodimers with class I factors. Class III factors are characterised by the presence of a leucine zipper () adjacent to the bHLH domain. Class IV factors may form homodimers or teterodimers with class III proteins. Class V and class VI proteins act as regulators of class I and class II factors and class VII proteins have a PAS domain ().
  IPR001092:Basic helix-loop-helix dimerisation region bHLH
IPR011598:HLH_DNA_bd 
Evalue:-26.0809211730957 
Location:319-400
SequencesProtein: SRBP1_HUMAN (1147 aa)
mRNA: NM_001005291 NM_004176
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK07197
  Level 3 annotation:
    HLH family transcriptional regulator, regulator for sterol biosynthesis and the LDL receptor gene
  Level 2 annotation:
    Insulin signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 261 residues, 17656110-17656890Exon2: 39 residues, 17657406-17657518Exon3: 69 residues, 17657607-17657808Exon4: 57 residues, 17658283-17658449Exon5: 46 residues, 17658653-17658786Exon6: 38 residues, 17658873-17658983Exon7: 38 residues, 17659259-17659368Exon8: 58 residues, 17659898-17660067Exon9: 57 residues, 17660245-17660412Exon10: 89 residues, 17660495-17660757Exon11: 61 residues, 17660996-17661175Exon12: 69 residues, 17661294-17661496Exon13: 75 residues, 17661734-17661955Exon14: 40 residues, 17662298-17662413Exon15: 76 residues, 17663051-17663273Exon16: 47 residues, 17663358-17663493Exon17: 64 residues, 17663576-17663764Exon18: 146 residues, 17664128-17664560Exon19: 32 residues, 17667556-17667646Exon20: 97 residues, 17680765-17681050Exon21: 2 residues, -Jump to SRBP1_HUMANExon1: 261 residues, 17656110-17656890Exon2: 39 residues, 17657406-17657518Exon3: 69 residues, 17657607-17657808Exon4: 57 residues, 17658283-17658449Exon5: 46 residues, 17658653-17658786Exon6: 38 residues, 17658873-17658983Exon7: 38 residues, 17659259-17659368Exon8: 58 residues, 17659898-17660067Exon9: 57 residues, 17660245-17660412Exon10: 89 residues, 17660495-17660757Exon11: 61 residues, 17660996-17661175Exon12: 69 residues, 17661294-17661496Exon13: 75 residues, 17661734-17661955Exon14: 40 residues, 17662298-17662413Exon15: 76 residues, 17663051-17663273Exon16: 47 residues, 17663358-17663493Exon17: 64 residues, 17663576-17663764Exon18: 146 residues, 17664128-17664560Exon19: 97 residues, 17680765-17681050Exon20: 2 residues, -Jump to SRBP1_HUMAN  
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Loci Cluster (Details)Loci: 4272 17862058-17883205 ~-21K 15261(ATPAF2)(-)Loci: 4271 17656110-17681050 ~-25K 15251(SREBF1)(-)Link out to UCSC