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0SPY2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSPRY2
DescriptionSprouty homolog 2 (spry-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007267 cell-cell signaling (TAS)
0009887 organogenesis (TAS)
0007165 signal transduction (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade. pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases . The sprouty gene has found to be expressed in the the brain.ochlea.asal organs.eeth.alivary gland.ungs.igestive tract.idneys and limb buds in mouse .
  IPR007875:Sprouty
IPR007875:Sprouty 
Evalue:-172.638275146484 
Location:36-294
SequencesProtein: SPY2_HUMAN (315 aa)
mRNA: NM_005842
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentK04704
  Level 3 annotation:
    sprouty
  Level 2 annotation:
    Jak-STAT signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 593 residues, 79808114-79809892Exon2: 112 residues, 79812757-79813087Exon3: 2 residues, -Jump to SPY2_HUMAN  
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