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0SPN90_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNCKIPSD
DescriptionSh3 adapter protein spin90 (nck-interacting protein with sh3 domain) (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia-interacting protein 1) (dip-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005882 intermediate filament (NAS)
0008092 cytoskeletal protein binding (NAS)
0007010 cytoskeleton organization and biogenesis (NAS)
0006607 NLS-bearing substrate-nucleus import (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR001452:SH3_1 
Evalue:-10.5228786468506 
Location:1-56
SequencesProtein: SPN90_HUMAN (722 aa)
mRNA: NM_016453 NM_184231
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 301 residues, 48686283-48687184Exon2: 59 residues, 48691000-48691173Exon3: 33 residues, 48691313-48691406Exon4: 45 residues, 48691491-48691620Exon5: 29 residues, 48691813-48691894Exon6: 48 residues, 48692011-48692150Exon7: 31 residues, 48692237-48692324Exon8: 59 residues, 48692495-48692666Exon9: 166 residues, 48693723-48694217Exon10: 32 residues, 48694481-48694572Exon11: 70 residues, 48694784-48694989Exon12: 38 residues, 48695339-48695449Exon13: 90 residues, 48698073-48698338Exon14: 2 residues, -Jump to SPN90_HUMANExon1: 301 residues, 48686283-48687184Exon2: 59 residues, 48691000-48691173Exon3: 33 residues, 48691313-48691406Exon4: 45 residues, 48691491-48691620Exon5: 29 residues, 48691813-48691894Exon6: 48 residues, 48692011-48692150Exon7: 31 residues, 48692237-48692324Exon8: 59 residues, 48692495-48692666Exon9: 166 residues, 48693723-48694217Exon10: 39 residues, 48694481-48694593Exon11: 70 residues, 48694784-48694989Exon12: 38 residues, 48695339-48695449Exon13: 90 residues, 48698073-48698338Exon14: 2 residues, -Jump to SPN90_HUMAN  
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Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC