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0SPHM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSGSH
DescriptionN-sulphoglucosamine sulphohydrolase precursor (ec 3.10.1.1) (sulfoglucosamine sulfamidase) (sulphamidase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003824 catalytic activity (TAS)
0006029 proteoglycan metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Sulfatases () are enzymes that hydrolyze various sulphate esters. The sequence of different types of sulphatases are available and have shown to be structurally related .ncluding arylsulphatase A () (ASA). lysosomal enzyme which hydrolyzes cerebroside sulphate; arylsulphatase B () (ASB).hich hydrolyzes the sulphate ester group from N-acetylgalactosamine 4-sulphate residues of dermatan sulphate; arylsulphatase C (ASD) and E (ASE);steryl-sulphatase () (STS). membrane bound microsomal enzyme which hydrolyzes 3-beta-hydroxy steroid sulphates; iduronate 2-sulphatase precursor () (IDS). lysosomal enzyme that hydrolyzes the 2-sulphate groups from non-reducing-terminal iduronic acid residues in dermatan sulphate and heparan sulphate; N-acetylgalactosamine-6-sulphatase ().hich hydrolyzes the 6-sulphate groups of the N-acetyl-d-galactosamine 6-sulphate units of chondroitin sulphate and the D-galactose 6-sulphate units of keratan sulphate; glucosamine-6-sulphatase () (G6S).hich hydrolyzes the N-acetyl-D-glucosamine 6-sulphate units of heparan sulphate and keratan sulphate; N-sulphoglucosamine sulphohydrolase () (sulphamidase).he lysosomal enzyme that catalyzes the hydrolysis of N-sulpho-d-glucosamine into glucosamine and sulphate; sea urchin embryo arylsulphatase (); green algae arylsulphatase ().hich plays an important role in the mineralization of sulphates; and arylsulphatase () from Escherichia coli (aslA).lebsiella aerogenes (gene atsA) and Pseudomonas aeruginosa (gene atsA).
  IPR000917:Sulfatase
IPR000917:Sulfatase 
Evalue:-80.5228805541992 
Location:21-450IPR000886:ER_TARGET 
Evalue:0 
Location:499-502
SequencesProtein: SPHM_HUMAN (502 aa)
mRNA: NM_000199
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01565
  Level 3 annotation:
    N-sulfoglucosamine sulfohydrolase
  Level 2 annotation:
    Glycosaminoglycan degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 574 residues, 75797684-75799405Exon2: 70 residues, 75800464-75800668Exon3: 29 residues, 75802197-75802279Exon4: 54 residues, 75802565-75802722Exon5: 52 residues, 75803008-75803159Exon6: 37 residues, 75803426-75803532Exon7: 55 residues, 75805425-75805586Exon8: 35 residues, 75808619-75808719Exon9: 2 residues, -Jump to SPHM_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4322 75797684-75808719 ~-11K 16775(SGSH)(-)Loci: 3044 75319275-75330615 ~-11K 16762(ENPP7)(+)Link out to UCSC