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0SPG16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSPAG16
DescriptionSperm-associated antigen 16 protein (pf20 protein homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001680:WD40 
Evalue:-10.3372421264648 
Location:426-464IPR001680:WD40 
Evalue:-10.050609588623 
Location:468-506IPR001680:WD40 
Evalue:-10 
Location:384-422IPR001680:WD40 
Evalue:-6.92081875395237 
Location:592-631IPR001680:WD40 
Evalue:-5.55284214019775 
Location:510-548IPR001680:WD40 
Evalue:-3.85387206077576 
Location:342-378IPR011046:WD40_like 
Evalue:0 
Location:7-40IPR001680:WD40 
Evalue:2 
Location:551-590
SequencesProtein: SPG16_HUMAN (631 aa)
mRNA: NM_024532
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 213857360-213857588Exon2: 17 residues, 213869032-213869079Exon3: 34 residues, 213870230-213870326Exon4: 41 residues, 213883027-213883146Exon5: 48 residues, 213890187-213890325Exon6: 38 residues, 213913131-213913239Exon7: 41 residues, 213923496-213923614Exon8: 25 residues, 213937044-213937114Exon9: 38 residues, 213947978-213948088Exon10: 44 residues, 214062931-214063059Exon11: 50 residues, 214435453-214435597Exon12: 64 residues, 214502928-214503114Exon13: 44 residues, 214586919-214587046Exon14: 24 residues, 214681164-214681230Exon15: 44 residues, 214722108-214722235Exon16: 122 residues, 214983108-214983469Exon17: 2 residues, -Jump to SPG16_HUMAN