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0SPEB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAgmatinase, mitochondrial precursor (ec (agmatine ureohydrolase) (auh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
L-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase and by the enzyme arginase as a part of the hepatic urea cycle. Arginase is a manganese metalloenzymes containing a metal-activated hydroxide ion. critical nucleophile in metalloenzymes that catalyze hydrolysis or hydration reactions. A hydrogen bond formed by the metal-bound hydroxide holds the enzyme in the proper orientation for catalysis however nonmetal substrate-binding sites are also implicated in the enzyme mechanism. Regeneration of metal-bound hydroxide ion from a metal-bound water molecule requires proton transfer to bulk solvent mediated by a histidine proton shuttle residue.
Members of this family include known and predicted examples of agmatinase (agmatine ureohydrolase. and members of archaea.or which no definitive agmatinase sequence has yet been made available. However.rchaeal sequences are phylogenetically close to the experimentally verified B. subtilis sequence. One species of Halobacterium has been demonstrated in vitro to produce agmatine from arginine.ut no putrescine from ornithine.uggesting that arginine decarboxylase and agmatinase.ather than arginase and ornithine decarboxylase.ead from arginine to polyamine biosynthesis.
  IPR005925:Putative agmatinase
The ureohydrolase superfamily includes arginase ().gmatinase ().ormiminoglutamase () and proclavaminate amidinohydrolase () . These enzymes share a 3-layer alpha-beta-alpha structure .nd play important roles in arginine/agmatine metabolism.he urea cycle.istidine degradation.nd other pathways. Arginase.hich catalyses the conversion of arginine to urea and ornithine.s one of the five members of the urea cycle enzymes that convert ammoniato urea as the principal product of nitrogen excretion . There are several arginase isozymes that differ in catalytic.olecular and immunological properties. Deficiency in the liver isozyme leads to argininemia.hich is usually associated with hyperammonemia.Agmatinase hydrolyses agmatine to putrescine.he precursor for the biosynthesis of higher polyamines.permidine and spermine. In addition.gmatine may play an important regulatory role in mammals. Formiminoglutamase catalyses the fourth step in histidine degradation.cting to hydrolyse N-formimidoyl-L-glutamate to L-glutamate and formamide. Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide range of beta-lactamase enzymes that are used by various microorganisms to resist beta-lactam antibiotics. As a result.his enzyme improves the effectiveness of beta-lactamase antibiotics .
SequencesProtein: SPEB_HUMAN (352 aa)
mRNA: NM_024758
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01480
  Level 3 annotation:
  Level 2 annotation:
    Arginine and proline metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 357 residues, 15771738-15772806Exon2: 30 residues, 15773838-15773923Exon3: 62 residues, 15776766-15776946Exon4: 67 residues, 15777940-15778136Exon5: 18 residues, 15779175-15779224Exon6: 69 residues, 15782274-15782477Exon7: 140 residues, 15783777-15784192Exon8: 2 residues, -Jump to SPEB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2483 15935395-15940471 ~-5K 460(+)Loci: 2484 15957841-15985673 ~-28K 462(FBLIM1)(+)Loci: 3772 15771738-15784192 ~-12K 455(AGMAT)(-)Link out to UCSC