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0SPAST_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSPAST
DescriptionSpastin.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A large family of ATPases has been described whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. This family is now called AAA.or ATPases Associated with diverse cellular Activities. The proteins that belong to this family either contain one or two AAA domains.It is proposed that.n general.he AAA domains in these proteins act as ATP-dependent protein clamps .In addition to the ATP-binding A and B motifs (see the relevant entry ).hich are located in the N-terminal half of this domain.here is a highly conserved region located in the central part of the domain.
  IPR003959:AAA ATPase, central region
The MIT domain is found in vacuolar sorting proteins.pastin (probable ATPase involved in the assembly or function of nuclear protein complexes).nd a sorting nexin.hich may play a role in intracellular trafficking.
  IPR007330:MIT
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
IPR003959:AAA 
Evalue:-77.1870880126953 
Location:377-562IPR007330:MIT 
Evalue:-19.3098039199715 
Location:116-194
SequencesProtein: SPAST_HUMAN (616 aa)
mRNA: NM_014946
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 213 residues, 32142183-32142819Exon2: 31 residues, 32166064-32166151Exon3: 30 residues, 32168094-32168178Exon4: 34 residues, 32177368-32177464Exon5: 64 residues, 32193210-32193398Exon6: 46 residues, 32194274-32194408Exon7: 33 residues, 32194691-32194785Exon8: 27 residues, 32205520-32205595Exon9: 26 residues, 32206980-32207052Exon10: 27 residues, 32215135-32215211Exon11: 32 residues, 32215449-32215541Exon12: 28 residues, 32215681-32215761Exon13: 16 residues, 32220476-32220519Exon14: 28 residues, 32221908-32221988Exon15: 25 residues, 32223509-32223580Exon16: 15 residues, 32225790-32225831Exon17: 1089 residues, 32232946-32236209Exon18: 2 residues, -Jump to SPAST_HUMAN  
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Loci Cluster (Details)Loci: 3157 32142183-32236209 ~-94K 20237(SPAST)(+)Loci: 4431 32102475-32118348 ~-16K 20236(-)Link out to UCSC