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0SOX9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSOX9
DescriptionTranscription factor sox-9.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0003704 specific RNA polymerase II transcription fa... (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
High mobility group (HMG or HMGB) proteins are a family of relatively low molecular weight non-histone components in chromatin. HMG1 (also called HMG-T in fish) and HMG2 are two highly related proteins that bind single-stranded DNA preferentially and unwind double-stranded DNA. Although they have no sequence specificity.hey have a high affinity for bent or distorted DNA.nd bend linear DNA. HMG1 and HMG2 contain two DNA-binding HMG-box domains (A and B) that show structural and functional differences.nd have a long acidic C-terminal domain rich in aspartic and glutamic acid residues. The acidic tail modulates the affinity of the tandem HMG boxes in HMG1 and 2 for a variety of DNA targets. HMG1 and 2 appear to play important architectural roles in the assembly of nucleoprotein complexes in a variety of biological processes.or example V(D)J recombination.he initiation of transcription.nd DNA repair .The profile in this entry describing the HMG-domains is much more general than the signature. In addition to the HMG1 and HMG2 proteins.MG-domains occur in single or multiple copies in the following protein classes; the SOX family of transcription factors; SRY sex determining region Y protein and related proteins ; LEF1 lymphoid enhancer binding factor 1 ; SSRP recombination signal recognition protein; MTF1 mitochondrial transcription factor 1; UBF1/2 nucleolar transcription factors; Abf2 yeast ARS-binding factor ; and Saccharomyces cerevisiae transcription factors Ixr1.ox1.hp6a.hp6b and Spp41.
  IPR000910:HMG1/2 (high mobility group) box
High mobility group (HMG) box domains are involved in binding DNA.nd may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins.hich form a large.iverse family involved in the regulation of DNA-dependent processes such as transcription.eplication.nd strand repair.ll of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms.nd can be broadly divided into two groups.ased on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif.hile the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors ; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation ; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor ; yeast transcription factors lxr1.ox1.hp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi ; and the YABBY plant-specific transcription factors. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009071:High mobility group box
IPR000910:HMG_box 
Evalue:-32.5528411865234 
Location:105-173
SequencesProtein: SOX9_HUMAN (509 aa)
mRNA: NM_000346
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 268 residues, 67628755-67629558Exon2: 86 residues, 67630454-67630708Exon3: 958 residues, 67631278-67634147Exon4: 2 residues, -Jump to SOX9_HUMAN  
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