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0SOCS1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSOCS1
DescriptionSuppressor of cytokine signaling 1 (socs-1) (jak-binding protein) (jab) (stat-induced stat inhibitor 1) (ssi-1) (tec-interacting protein 3) (tip-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005159 insulin-like growth factor receptor binding (IPI)
0019901 protein kinase binding (IPI)
0004860 protein kinase inhibitor activity (TAS)
0007259 JAK-STAT cascade (TAS)
0046426 negative regulation of JAK-STAT cascade (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signaling (SOCS) family but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family.he SSB (SPRY domain-containing proteins with a SOCS box) family.he ASB (ankyrin-repeat-containing proteins with a SOCS box) family.nd ras and ras-like GTPases .The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 nonconserved residues . The C-terminal conserved region is an L/P-rich sequence of unknown function.hereas the N-terminal conserved region is a consensus BC box .hich binds to the Elongin BC complex . It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments .
  IPR001496:SOCS protein, C-terminal
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps . Similar sequences were later found in many other intracellular signal-transducing proteins . SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine-containing target peptides in a sequence-specific.H2 domains recognize between 3-6 residues C-terminal to the phosphorylated tyrosine in a fashion that differs fromone SH2 domain to another.nd strictly phosphorylation-dependent manner . They are found in a wide variety of protein contexts e.g..n association with catalytic domains of phospholipase Cy (PLCy) and the non-receptor protein tyrosine kinases; within structural proteins such as fodrin and tensin; and in a group of small adaptor molecules..e Crk and Nck. The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. The structure of the SH2 domain belongs to the alpha+beta class.ts overall shape forming a compact flattened hemisphere. The core structural elements comprise a central hydrophobic anti-parallel beta-sheet.lanked by 2 short alpha-helices. The loop between strands 2 and 3 provides many of the binding interactions with the phosphate group of its phosphopeptide ligand.nd is hence designated the phosphate binding loop.he phosphorylated ligand binds perpendicular to the beta-sheet and typically interacts with the phosphate binding loop and a hydrophobic binding pocket that interacts with a pY+3 side chain. The N- and C-termini of the domain are close together in space and on the opposite face from the phosphopeptide binding surface and it has been speculated that this has facilitated their integration into surface-exposed regions of host proteins .
  IPR000980:SH2 motif
IPR000980:SH2 
Evalue:-20.6575773191778 
Location:77-160IPR001496:SOCS 
Evalue:-14.2924298239021 
Location:165-208
SequencesProtein: SOCS1_HUMAN (211 aa)
mRNA: NM_003745
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 371 residues, 11255774-11256886Exon2: 36 residues, 11257436-11257540Exon3: 2 residues, -Jump to SOCS1_HUMAN  
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