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0SNX17_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSNX17
DescriptionSorting nexin-17.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005769 early endosome (IDA)
0016020 membrane (NAS)
0008022 protein C-terminus binding (IPI)
0005102 receptor binding (NAS)
0016197 endosome transport (NAS)
0006886 intracellular protein transport (NAS)
0045192 low-density lipoprotein catabolism (NAS)
0030100 regulation of endocytosis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The PX (phox) domain occurs in a variety of eukaryotic proteins and have been implicated in highly diverse functions such as cell signalling.esicular trafficking.rotein sorting and lipid modification . PX domains are important phosphoinositide-binding modules that have varying lipid-binding specificities .The PX domain is approximately 120 residues long .nd folds into a three-stranded beta-sheet followed by three -helices and a proline-rich region that immediately preceeds a membrane-interaction loop and spans approximately eight hydrophobic and polar residues. The PX domain of p47phox binds to the SH3 domain in the same protein. Phosphorylation of p47(phox). cytoplasmic activator of the microbicidal phagocyte oxidase (phox).licits interaction of p47(phox) with phoinositides. The protein phosphorylation-driven conformational change of p47(phox) enables its PX domain to bind to phosphoinositides.he interaction of which plays a crucial role in recruitment of p47(phox) from the cytoplasm to membranes and subsequent activation of the phagocyte oxidase. The lipid-binding activity of this protein is normally suppressed by intramolecular interaction of the PX domain with the C-terminal Src homology 3 (SH3) domain .The PX domain is conserved from yeast to human. A recent multiple alignment of representative PX domain sequences can be found in .lthough showing relatively little sequence conservation.heir structure appears to be highly conserved. Although phosphatidylinositol-3-phosphate (PtdIns(3)P) is the primary target of PX domains.inding to phosphatidic acid.hosphatidylinositol-3.-bisphosphate (PtdIns(3.)P2).hosphatidylinositol-3.-bisphosphate (PtdIns(3.)P2).hosphatidylinositol-4.-bisphosphate (PtdIns(4.)P2).nd phosphatidylinositol-3..-trisphosphate (PtdIns(3..)P3) has been reported as well. The PX-domain is also a protein-protein interaction domain .
  IPR001683:Phox-like
IPR001683:PX 
Evalue:-25.8538722991943 
Location:1-105IPR000159:RA 
Evalue:0 
Location:115-206
SequencesProtein: SNX17_HUMAN (470 aa)
mRNA: NM_014748
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 27446892-27447177Exon2: 27 residues, 27447639-27447714Exon3: 41 residues, 27448993-27449111Exon4: 23 residues, 27449617-27449682Exon5: 39 residues, 27450231-27450342Exon6: 32 residues, 27450455-27450546Exon7: 31 residues, 27450716-27450804Exon8: 25 residues, 27451059-27451129Exon9: 33 residues, 27451431-27451524Exon10: 70 residues, 27451876-27452080Exon11: 44 residues, 27452216-27452342Exon12: 28 residues, 27452476-27452554Exon13: 27 residues, 27452683-27452758Exon14: 16 residues, 27452849-27452891Exon15: 176 residues, 27452976-27453498Exon16: 2 residues, -Jump to SNX17_HUMAN  
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Loci Cluster (Details)Loci: 3152 27047028-27103590 ~-57K 20131(MAPRE3)(+)Loci: 3153 27155437-27162767 ~-7K 20145(EMILIN1)(+)Loci: 4428 27207130-27211046 ~-4K 20152(PREB)(-)Loci: 4429 27330944-27339464 ~-9K 20162(SLC30A3)(-)Loci: 3154 27446892-27453498 ~-7K 20173(SNX17)(+)Loci: 3155 27848089-27856103 ~-8K 20199(+)Loci: 3151 26924466-27024572 ~-100K 20130(DPYSL5)(+)Link out to UCSC