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0SNCAP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSNCAIP
DescriptionSynphilin-1 (alpha-synuclein-interacting protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0043025 cell soma (NAS)
0005737 cytoplasm (TAS)
0042734 presynaptic membrane (NAS)
0005515 protein binding (IPI)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
IPR002110:Ank 
Evalue:-7.48148584365845 
Location:456-488IPR002110:Ank 
Evalue:-2.32790207862854 
Location:349-369IPR002110:ANK 
Evalue:0 
Location:895-917IPR002110:Ank 
Evalue:0.826074779033661 
Location:425-455IPR002110:ANK 
Evalue:1.91381385238372 
Location:384-413
SequencesProtein: SNCAP_HUMAN (919 aa)
mRNA: AB110790 BC040552 NM_005460
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
KO assignmentK04558
  Level 3 annotation:
    synuclein, alpha interacting protein (synphilin)
  Level 2 annotation:
    Parkinson's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 121675718-121675878Exon2: 36 residues, 121754682-121754785Exon3: 26 residues, 121767386-121767459Exon4: 292 residues, 121786461-121787333Exon5: 62 residues, 121788945-121789125Exon6: 40 residues, 121795562-121795676Exon7: 44 residues, 121804222-121804348Exon8: 58 residues, 121808156-121808326Exon9: 33 residues, 121813438-121813531Exon10: 358 residues, 121814126-121815195Exon11: 205 residues, 121827084-121827693Exon12: 2 residues, -Jump to SNCAP_HUMANExon1: 27 residues, 121675800-121675878Exon2: 436 residues, 121752160-121753464Exon3: 36 residues, 121754682-121754785Exon4: 49 residues, 121764579-121764720Exon5: 26 residues, 121767386-121767459Exon6: 292 residues, 121786461-121787333Exon7: 62 residues, 121788945-121789125Exon8: 40 residues, 121795562-121795676Exon9: 44 residues, 121804222-121804348Exon10: 58 residues, 121808156-121808326Exon11: 33 residues, 121813438-121813531Exon12: 358 residues, 121814126-121815195Exon13: 25 residues, 121816518-121816589Exon14: 190 residues, 121827084-121827648Exon15: 2 residues, -Jump to SNCAP_HUMANExon1: 20 residues, 121754728-121754785Exon2: 49 residues, 121764579-121764720Exon3: 26 residues, 121767386-121767459Exon4: 292 residues, 121786461-121787333Exon5: 62 residues, 121788945-121789125Exon6: 40 residues, 121795562-121795676Exon7: 44 residues, 121804222-121804348Exon8: 40 residues, 121807164-121807279Exon9: 38 residues, 121807679-121807789Exon10: 58 residues, 121808156-121808326Exon11: 33 residues, 121813438-121813531Exon12: 358 residues, 121814126-121815196Exon13: 2 residues, -Jump to SNCAP_HUMAN  
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