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0SMRC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSMARCC2
DescriptionSwi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily c member 2 (swi/snf complex 170 kda subunit) (brg1-associated factor 170).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005654 nucleoplasm (TAS)
0016514 SWI/SNF complex (IDA)
0005515 protein binding (IPI)
0003713 transcription coactivator activity (TAS)
0006338 chromatin remodeling (IDA)
0045892 negative regulation of transcription, DNA-d... (IDA)
0045893 positive regulation of transcription, DNA-d... (IDA)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in eukaryotic chromosomal proteins. It is named after the proteins SWI3.SC8 and MOIRA in which it was first recognised. This domain is predicted to mediate protein-protein interactions in the assembly of chromatin-protein complexes. The SWIRM domain can be linked to different domains.uch as the ZZ-type zinc finger ().he Myb DNA-binding domain ().he HORMA domain ().he amino-oxidase domain.he chromo domain ().nd the JAB1/PAD1 domain.
  IPR007526:SWIRM
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
The CHROMO (CHRromatin Organization MOdifier) domain .s a conserved region of around 60 amino acids.riginally identified in Drosophila modifiers of variegation.These are proteins that alter the structure of chromatin to the condensed morphology of heterochromatin. cytologically visible condition where gene expression is repressed. In one of these proteins.olycomb.he chromo domain has been shown to be important for chromatin targeting. Proteins that contain a chromo domain appear to fall into 3 classes. The first class includes proteins having an N-terminal chromo domain followed by a region termed the chromo shadow domain .g. Drosophila and human heterochromatin protein Su(var)205 (HP1). The second class includes proteins with a single chromo domain.g. Drosophila protein Polycomb (Pc); mammalian modifier 3; human Mi-2 autoantigenand and several yeast and Caenorhabditis elegans hypothetical proteins. In the third class paired tandem chromo domains are found.g. in mammalian DNA-binding/helicase proteins CHD-1 to CHD-4 and yeast protein CHD1.
  IPR000953:Chromo
Homeodomain proteins are transcription factors that share a related DNA binding homeodomain . The homeodomain was first identified in a number of Drosophila homeotic and segmentation proteins.ut is now known to be well conserved in many other animals.ncluding vertebrates. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha helices.hich make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions.hich occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. Many proteins contain homeodomains.ncluding Drosophila Engrailed.east mating type proteins.epatocyte nuclear factor 1a and HOX proteins.The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins.ncluding recombinases.yb proteins.ARP response regulators.uman telomeric proteins (hTRF1).aired domain proteins (PAX).east RAP1.entromere-binding proteins CENP-B and ABP-1.ranscriptional regulators (TyrR).raC-type transcriptional activators.nd tetracycline repressor-like proteins (TetR.acR.cdC) .
  IPR012287:Homeodomain-related
IPR007526:SWIRM 
Evalue:-43.0604820251465 
Location:424-512IPR001005:SANT 
Evalue:-11.0555173278498 
Location:597-645IPR000953:CHROMO 
Evalue:-5.21467016498923 
Location:186-235IPR001005:MYB_1 
Evalue:0 
Location:0-0
SequencesProtein: SMRC2_HUMAN (1214 aa)
mRNA: NM_003075
Local Annotation
Synapse Ontology
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 141 residues, 54843395-54843816Exon2: 145 residues, 54844353-54844782Exon3: 129 residues, 54845368-54845750Exon4: 47 residues, 54848110-54848245Exon5: 57 residues, 54849579-54849746Exon6: 47 residues, 54849826-54849962Exon7: 23 residues, 54850194-54850259Exon8: 56 residues, 54851321-54851483Exon9: 88 residues, 54851729-54851988Exon10: 23 residues, 54852478-54852541Exon11: 42 residues, 54852635-54852755Exon12: 53 residues, 54853746-54853900Exon13: 40 residues, 54854701-54854815Exon14: 26 residues, 54858072-54858144Exon15: 45 residues, 54858454-54858585Exon16: 14 residues, 54858860-54858898Exon17: 22 residues, 54859047-54859107Exon18: 43 residues, 54861027-54861152Exon19: 40 residues, 54861532-54861648Exon20: 46 residues, 54861754-54861886Exon21: 27 residues, 54862054-54862130Exon22: 25 residues, 54863911-54863981Exon23: 25 residues, 54864225-54864295Exon24: 33 residues, 54864894-54864987Exon25: 29 residues, 54865080-54865162Exon26: 30 residues, 54866205-54866291Exon27: 42 residues, 54867237-54867357Exon28: 49 residues, 54869401-54869544Exon29: 2 residues, -Jump to SMRC2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2763 54396087-54399754 ~-4K 9024(BLOC1S1)(+)Loci: 2764 54423333-54430331 ~-7K 9030(GDF11)(+)Loci: 2765 54654128-54674745 ~-21K 9056(RAB5B)(+)Loci: 2766 54677309-54685574 ~-8K 9057(SUOX)(+)Loci: 2767 54798296-54802545 ~-4K 9067(+)Loci: 4051 54843395-54869544 ~-26K 9082(SMARCC2)(-)Loci: 4052 54951749-54980442 ~-29K 9095(CS)(-)Loci: 4053 55151003-55168448 ~-17K 9108(GLS2)(-)Loci: 4054 55275981-55316430 ~-40K 9114(BAZ2A)(-)Loci: 4055 55318225-55326119 ~-8K 9115(ATP5B)(-)Loci: 4056 55708568-55730160 ~-22K 9128(MYO1A)(-)Loci: 4050 54364622-54387894 ~-23K 9022(ITGA7)(-)Link out to UCSC