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0SMOX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSpermine oxidase (ec 1.5.3.-) (polyamine oxidase 1) (pao-1) (paoh1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
This entry consists of various amine oxidases.ncluding maize polyamine oxidase (PAO) .-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of theseenzymes.In vertebrates MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters.eurotoxins and trace amines . In lower eukaryotessuch as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium .PAOs in plants.acteria and protozoa oxidise spermidine and spermine to an aminobutyral.iaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines .Other members of this family include tryptophan 2-monooxygenase.utrescine oxidase.orticosteroid binding proteins and antibacterial glycoproteins.
  IPR002937:Amine oxidase
InterPro domains unassigned to SynO:
Mitochondrial P450-containing systems comprise 3 components.n FAD-containing flavoprotein NADPH:adrenodoxin reductase (AR); an iron-sulphur protein.drenodoxin; and P450 . The direction of electron flow is NADPH to AR to adrenodoxin to P450. FAD can be reduced by 2 electrons from NADPH.hich are transferred one at a time to adrenodoxin. one-electron carrier. Both AR and adrenodoxin are soluble proteins located on the matrix side of the inner mitochondrial membrane. Despite functional parallels.R shows no global similarity either to flavoprotein pyridine nucleotide cytochrome reductases (FPNCR) or to FAD-dependent pyridine nucleotide reductases (FADPNR) . However.LAST searches reveal local similarity of the N-terminal region of AR to glutamate synthase and NADH peroxidase.specially in the nucleotide-binding regions.uggesting that AR and FADPNR may be distantly related.
  IPR000759:Adrenodoxin reductase
SequencesProtein: SMOX_HUMAN (555 aa)
mRNA: NM_019025
Local Annotation
Synapse Ontology
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentK00309
  Level 3 annotation:
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 4100356-4100552Exon2: 80 residues, 4103676-4103910Exon3: 77 residues, 4105997-4106224Exon4: 60 residues, 4110449-4110623Exon5: 255 residues, 4110735-4111495Exon6: 55 residues, 4112140-4112301Exon7: 153 residues, 4115916-4116369Exon8: 2 residues, -Jump to SMOX_HUMAN  
Loci Cluster (Details)Loci: 3232 3817741-3852501 ~-35K 22637(PANK2)(+)Loci: 3233 4100356-4116369 ~-16K 22645(SMOX)(+)Loci: 3231 3724400-3734759 ~-10K 22628(CDC25B)(+)Link out to UCSC