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0SMN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSMN1
DescriptionSurvival motor neuron protein (component of gems 1) (gemin-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015030 Cajal body (NAS)
0005737 cytoplasm (NAS)
0005515 protein binding (IPI)
0000245 spliceosome assembly (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein.he product of the spinal muscular atrophy-determining gene.s part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit.nd potentially deleterious.on-specific binding of Sm proteins to RNAs.
  IPR010304:Survival motor neuron
The drosophila tudor protein is encoded by a posterior group gene.hich when mutated disrupt normal abdominal segmentation and polecell formation. Another drosophila gene.omeless.s required forRNA localization during oogenesis. The tudor protein containsmultiple repeats of a domain which is also found in homeless .The tudor domain is found in many proteins that colocalize withribonucleoprotein or single-strand DNA-associated complexes in thenucleus.n the mitochondrial membrane.r at kinetochores.It is not known whether the domain binds directly to RNA and ssDNA.rcontrols interactions with the nucleoprotein complexes. At least onetudor-containing protein.omeless.lso contains a zinc fingertypical of RNA-binding proteins .
  IPR002999:Tudor
IPR010304:SMN 
Evalue:-127.455932617187 
Location:26-293
SequencesProtein: SMN_HUMAN (294 aa)
mRNA: NM_000344 NM_017411
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 58 residues, 70051445-70051616Exon2: 13 residues, 70081159-70081193Exon3: 54 residues, 70082659-70082815Exon4: 64 residues, 70117020-70117208Exon5: 30 residues, 70120790-70120875Exon6: 60 residues, 70122714-70122889Exon7: 167 residues, 70327360-70327856Exon8: 2 residues, -Jump to GUSL2_HUMANExon1: 64 residues, 70232269-70232459Exon2: 38 residues, 70233407-70233516Exon3: 531 residues, 70248523-70250112Exon4: 2 residues, -Jump to SERF1_HUMANExon1: 82 residues, 70256523-70256767Exon2: 26 residues, 70270421-70270493Exon3: 42 residues, 70272971-70273091Exon4: 69 residues, 70273940-70274141Exon5: 53 residues, 70274300-70274453Exon6: 34 residues, 70276240-70276336Exon7: 39 residues, 70277648-70277759Exon8: 20 residues, 70283523-70283577Exon9: 192 residues, 70284021-70284592Exon10: 2 residues, -Jump to SMN_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 58 residues, 69176325-69176496Exon2: 13 residues, 69205246-69205280Exon3: 54 residues, 69206746-69206902Exon4: 64 residues, 69241957-69242145Exon5: 30 residues, 69245740-69245825Exon6: 60 residues, 69247663-69247838Exon7: 177 residues, 69451887-69452412Exon8: 2 residues, -Jump to GUSL2_HUMANExon1: 64 residues, 69356851-69357041Exon2: 38 residues, 69357989-69358098Exon3: 531 residues, 69373106-69374695Exon4: 2 residues, -Jump to SERF1_HUMANExon1: 82 residues, 69381105-69381349Exon2: 26 residues, 69394997-69395069Exon3: 42 residues, 69397547-69397667Exon4: 69 residues, 69398516-69398717Exon5: 53 residues, 69398876-69399029Exon6: 34 residues, 69400817-69400913Exon7: 39 residues, 69402223-69402334Exon8: 20 residues, 69408103-69408157Exon9: 192 residues, 69408601-69409172Exon10: 2 residues, -Jump to SMN_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 191 residues, 465177-465748Exon2: 20 residues, 466192-466246Exon3: 39 residues, 472009-472120Exon4: 34 residues, 473430-473526Exon5: 53 residues, 475313-475466Exon6: 69 residues, 475625-475826Exon7: 42 residues, 476675-476795Exon8: 26 residues, 479273-479345Exon9: 83 residues, 492998-493242Exon10: 2 residues, -Jump to SMN_HUMAN  
Loci Cluster (Details)Loci: 4716 70300065-70356279 ~-56K 28969(BIRC1)(-)Loci: 3462 70051445-70327856 ~-276K 28960(SMA3)(+)Link out to UCSC  
Loci: 3515 393545-449737 ~-56K 30164(BIRC1)(+)Loci: 4764 465177-493242 ~-28K 30167(SMN1)(-)Loci: 4765 499652-517517 ~-18K 30169(SERF1A)(-)Loci: 4766 621245-720436 ~-99K 30171(SMA3)(-)Loci: 3514 160403-205618 ~-45K 30155(RAD17)(+)Link out to UCSC