SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0SLAF6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLAMF6
DescriptionSlam family member 6 precursor (nk-t-b-antigen) (ntb-a) (activating nk receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . This subfamily includes:Cell surface receptors containing an immunoglobin domain.Killer cell inhibitory receptors.Oprin a snake venom metalloproteinase inhibitor from Didelphis marsupialis (Southern opossum) .hich belongs to MEROPS inhibitor family I43.lan I- .Oprin homologues.
  IPR003599:Immunoglobulin subtype
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . This entry represents the V-set domains.hich are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families.ncluding immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2).D4.D80.nd CD86; in myelin membrane adhesion molecules; in junction adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1).
  IPR013106:Immunoglobulin V-set
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR003599:IG 
Evalue:-3.58502665202918 
Location:27-127IPR013783:Ig-like_fold 
Evalue:0 
Location:148-209
SequencesProtein: SLAF6_HUMAN (332 aa)
mRNA: AL832854 BC090928 NM_052931
Local Annotation
Synapse Ontology
A typical resting membrane potential for neurons varies from -65 to -90 mV. This potential represents the sum of the equilibrium potentials for each contributing ion.
sdb:0237 resting membrane potentiaion  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 576 residues, 158721443-158723168Exon2: 26 residues, 158723517-158723589Exon3: 28 residues, 158725501-158725581Exon4: 15 residues, 158726611-158726650Exon5: 39 residues, 158726988-158727099Exon6: 90 residues, 158727538-158727802Exon7: 113 residues, 158732474-158732807Exon8: 38 residues, 158759557-158759666Exon9: 2 residues, -Jump to SLAF6_HUMANExon1: 573 residues, 158721452-158723168Exon2: 26 residues, 158723517-158723589Exon3: 385 residues, 158725501-158726650Exon4: 39 residues, 158726988-158727099Exon5: 90 residues, 158727538-158727802Exon6: 113 residues, 158732474-158732807Exon7: 35 residues, 158759557-158759657Exon8: 2 residues, -Jump to SLAF6_HUMANExon1: 563 residues, 158721482-158723168Exon2: 26 residues, 158723517-158723589Exon3: 29 residues, 158725501-158725584Exon4: 15 residues, 158726611-158726650Exon5: 39 residues, 158726988-158727099Exon6: 90 residues, 158727538-158727802Exon7: 113 residues, 158732474-158732807Exon8: 35 residues, 158759557-158759657Exon9: 2 residues, -Jump to SLAF6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2563 158352171-158379996 ~-28K 3053(ATP1A2)(+)Loci: 2564 158441750-158451784 ~-10K 3060(PEA15)(+)Loci: 3841 158721443-158759666 ~-38K 3073(SLAMF6)(-)Loci: 3842 158846513-158883493 ~-37K 3083(SLAMF1)(-)Loci: 2562 158317983-158325836 ~-8K 3047(KCNJ9)(+)Link out to UCSC