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0SLAF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLAMF1
DescriptionSignaling lymphocytic activation molecule precursor (ipo-3) (cd150 antigen) (cdw150).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003823 antigen binding (TAS)
0004888 transmembrane receptor activity (TAS)
0019735 antimicrobial humoral response (sensu Verte... (TAS)
0008284 positive regulation of cell proliferation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry is found in several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM. 70 kDa co-stimulatory molecule belonging to the Ig superfamily.s defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones . SLAM has also been recognised as a receptor for measles virus .
  IPR010407:Signaling lymphocytic activation molecule, N-terminal
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR010407:SLAM 
Evalue:-103.180458068848 
Location:1-126IPR007110:IG_LIKE 
Evalue:0 
Location:144-223
SequencesProtein: SLAF1_HUMAN (335 aa)
mRNA: NM_003037
Local Annotation
Synapse Ontology
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK06536
  Level 3 annotation:
    signaling lymphocytic activation molecule family member 1
  Level 2 annotation:
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 234 residues, 158846513-158847212Exon2: 33 residues, 158848901-158848994Exon3: 26 residues, 158856189-158856263Exon4: 32 residues, 158860509-158860599Exon5: 97 residues, 158871026-158871311Exon6: 115 residues, 158873604-158873943Exon7: 72 residues, 158883283-158883493Exon8: 2 residues, -Jump to SLAF1_HUMAN  
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Loci Cluster (Details)Loci: 2563 158352171-158379996 ~-28K 3053(ATP1A2)(+)Loci: 2564 158441750-158451784 ~-10K 3060(PEA15)(+)Loci: 3841 158721443-158759666 ~-38K 3073(SLAMF6)(-)Loci: 3842 158846513-158883493 ~-37K 3083(SLAMF1)(-)Loci: 2562 158317983-158325836 ~-8K 3047(KCNJ9)(+)Link out to UCSC