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0SL9A8_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC9A8
DescriptionSodium/hydrogen exchanger 8 (na(+)/h(+) exchanger 8) (nhe-8) (solute carrier family 9 member 8).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The monovalent Cation:Proton antiporter-1 (CPA1) family is a large family of proteins derived from Gram-positive and Gram-negative bacteria.lue green bacteria.east.lants and animals. Transporters from eukaryotes have been functionally characterized.nd all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in cytoplasmic pH regulation.xtruding the H+ generated during metabolism.nd salt tolerance (in plants).ue to Na+ uptake into vacuoles. Na+/H+ exchange proteins eject protons from cells.ffectively eliminating excess acid from actively metabolising cells. Na+/H+ exchange activity is also crucial for the regulation of cell volume.nd for the reabsorption of NaCl across renal.ntestinal.nd other epithelia. These antiports exchange Na+ for H+ in an electroneutral manner.nd this activity is carried out by a family of Na+/H+ exchangers.r NHEs.hich are known to be present in both prokaryotic and eukaryotic cells. In mammalian cells.a+/H+ exchange activity is found in both the plasma membrane and inner mitochondrial membrane. To date.ix mammalian isoforms have been identified (designated NHE1-NHE6) . These exchangers are highly-regulated (glyco)phosphoproteins.hich.ased on their primary structure.ppear to contain 10-12 membrane-spanning regions (M) at the N-terminus and a large cytoplasmic region at the C-terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus.his is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. There is some evidence that the exchangers may exist in the cell membrane as homodimers.ut little is currently known about the mechanism of their antiport .
  IPR006153:Sodium/hydrogen exchanger
Na+/H+ exchange proteins eject protons from cells.ffectively eliminating excess acid from actively metabolising cells. Na+/H+ exchange activity is also crucial for the regulation of cell volume.nd for the reabsorption of NaCl across renal.ntestinal.nd other epithelia. These antiports exchange Na+ for H+ in an electroneutral manner.nd this activity is carried out by a family of Na+/H+ exchangers.r NHEs.hich are known to be present in both prokaryotic and eukaryotic cells. In mammalian cells.a+/H+ exchange activity is found in both the plasma membrane and inner mitochondrial membrane. To date.ix mammalian isoforms have been identified (designated NHE1-NHE6) . These exchangers are highly-regulated (glyco)phosphoproteins.hich.ased on their primary structure.ppear to contain 10-12 membrane-spanning regions (M) at the N-terminus and a large cytoplasmic region at the C-terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus.his is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. There is some evidence that the exchangers may exist in the cell membrane as homodimers.ut little is currently known about the mechanism of their antiport .
  IPR004709:Sodium/hydrogen exchanger subfamily
IPR006153:Na_H_Exchanger 
Evalue:-73.0506134033203 
Location:58-469
SequencesProtein: SL9A8_HUMAN (577 aa)
mRNA: BC112213 NM_015266
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 79 residues, 47862656-47862892Exon2: 62 residues, 47864951-47865133Exon3: 29 residues, 47873004-47873085Exon4: 21 residues, 47889484-47889543Exon5: 30 residues, 47894979-47895063Exon6: 36 residues, 47899522-47899624Exon7: 13 residues, 47900753-47900788Exon8: 50 residues, 47905381-47905525Exon9: 48 residues, 47912872-47913011Exon10: 37 residues, 47914682-47914788Exon11: 41 residues, 47924648-47924765Exon12: 29 residues, 47927924-47928007Exon13: 39 residues, 47930867-47930979Exon14: 75 residues, 47933789-47934010Exon15: 51 residues, 47936695-47936842Exon16: 1471 residues, 47937772-47942179Exon17: 2 residues, -Jump to SL9A8_HUMANExon1: 20 residues, 47862834-47862892Exon2: 62 residues, 47864951-47865133Exon3: 29 residues, 47873004-47873085Exon4: 21 residues, 47889484-47889543Exon5: 30 residues, 47894979-47895063Exon6: 36 residues, 47899522-47899624Exon7: 13 residues, 47900753-47900788Exon8: 50 residues, 47905381-47905525Exon9: 48 residues, 47912872-47913011Exon10: 37 residues, 47914682-47914788Exon11: 41 residues, 47924648-47924765Exon12: 29 residues, 47927924-47928007Exon13: 39 residues, 47930867-47930979Exon14: 75 residues, 47933789-47934010Exon15: 51 residues, 47936695-47936842Exon16: 65 residues, 47937772-47937963Exon17: 2 residues, -Jump to SL9A8_HUMAN  
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Loci Cluster (Details)Loci: 4529 48131069-48203667 ~-73K 23328(UBE2V1)(-)Loci: 3264 47862656-47942179 ~-80K 23321(SLC9A8)(+)Link out to UCSC