SynDB Home Page
SynDB Home Page

blue bulletSynDB protein details  

Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0SIRT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNad-dependent deacetylase sirtuin-2 (ec 3.5.1.-) (sir2-like) (sir2- like protein 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005677 chromatin silencing complex (NAS)
0005737 cytoplasm (IDA)
0005874 microtubule (IDA)
0035035 histone acetyltransferase binding (IPI)
0042826 histone deacetylase binding (IPI)
0017136 NAD-dependent histone deacetylase activity (IDA)
0008134 transcription factor binding (IPI)
0042903 tubulin deacetylase activity (IDA)
0043130 ubiquitin binding (IDA)
0008270 zinc ion binding (IDA)
0000183 chromatin silencing at ribosomal DNA (NAS)
0006348 chromatin silencing at telomere (NAS)
0016575 histone deacetylation (TAS)
0045843 negative regulation of myogenesis (IDA)
0016481 negative regulation of transcription (IDA)
0006471 protein amino acid ADP-ribosylation (NAS)
0006980 redox signal response (NAS)
0007096 regulation of exit from mitosis (NAS)
0042325 regulation of phosphorylation (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/ [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
These sequences represent the Sir2 family of NAD+-dependent deacetylases. Silent Information Regulator protein of Saccharomyces cerevisiae (Sir2p) is one of several factors criticalfor silencing at least three loci. Among them.t is unique becauseit silences the rDNA as well as the mating type loci and telomeres. Sir2pinteracts in a complex with itself and with Sir3p and Sir4p.wo proteins thatare able to interact with nucleosomes. In addition Sir2p also interacts withubiquitination factors and/or complexes .Unlike Sir3p and Sir4p.or which no homologues are known.ir2p is part of amultigene family in yeast.he homolgues being HST1.ST2.ST3 and HST4. Highly conserved structural homologues also occur in other organisms ranging from bacteria to man and plants. Proteins of this family have been proposed to play a role insilencing.hromosome stability and ageing. In addition.n invitro ADP ribosyltransferase activity has been associated with Escherichia coli andhuman members of this family .Homologues of Sir2 share a core domain including the GAG and NID motifs and aputative C4 Zinc finger. The regions containing these three conserved motifsare individually essential for Sir2 silencing function.s are the fourcysteins . In addition.he conserved residues HG next to the putative Znfinger have been shown to be essential for the ADP ribosyltransferase activity. Sir2-like enzymes catalyze a reaction in which the cleavage of NAD(+)and histone and/or protein deacetylation are coupled to the formation of O-acetyl-ADP-ribose. novel metabolite. The dependence of the reaction on both NAD(+) and the generation of this potential second messenger offers new clues to understanding the function and regulation of nuclear.ytoplasmic and mitochondrial Sir2-like enzymes .
  IPR003000:Silent information regulator protein Sir2
SequencesProtein: SIRT2_HUMAN (389 aa)
mRNA: NM_012237
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentK01463
  Level 3 annotation:
  Level 2 annotation:
    Nicotinate and nicotinamide metabolism
    Pantothenate and CoA biosynthesis
    Caprolactam degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 250 residues, 44061041-44061790Exon2: 24 residues, 44061913-44061980Exon3: 25 residues, 44062111-44062182Exon4: 19 residues, 44063164-44063216Exon5: 27 residues, 44063300-44063377Exon6: 20 residues, 44063579-44063635Exon7: 22 residues, 44063911-44063971Exon8: 45 residues, 44066106-44066236Exon9: 25 residues, 44071566-44071635Exon10: 21 residues, 44072168-44072225Exon11: 37 residues, 44072334-44072441Exon12: 16 residues, 44072582-44072624Exon13: 40 residues, 44075893-44076007Exon14: 18 residues, 44076298-44076347Exon15: 17 residues, 44080858-44080905Exon16: 74 residues, 44081985-44082201Exon17: 2 residues, -Jump to SIRT2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3108 43830166-43913010 ~-83K 18756(ACTN4)(+)Loci: 4387 43953451-43955988 ~-3K 18760(LGALS7)(-)Loci: 3109 43971693-43974232 ~-3K 18761(LGALS7)(+)Loci: 4388 44061041-44082201 ~-21K 18769(SIRT2)(-)Loci: 3110 44082454-44091373 ~-9K 18775(NFKBIB)(+)Loci: 4389 44097746-44113376 ~-16K 18777(SARS2)(-)Loci: 3111 44113187-44115497 ~-2K 18779(MRPS12)(+)Loci: 3112 44308259-44361886 ~-54K 18787(PAK4)(+)Loci: 3107 43616179-43770042 ~-154K 18750(RYR1)(+)Link out to UCSC