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0SHLB1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSH3GLB1
DescriptionSh3 domain grb2-like protein b1 (ec 2.3.1.-) (endophilin b1) (bax- interacting factor 1) (bif-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Endocytosis and intracellular transport involve several mechanistic steps: (1) for the internalisation of cargo molecules.he membrane needs to bend to form a vesicular structure.hich requires membrane curvature and a rearrangement of the cytoskeleton; (2) following its formation.he vesicle has to be pinched off the membrane; (3) the cargo has to be subsequently transported through the cell and the vesicle must fuse with the correct cellular compartment.Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis.nvolved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain.nown as the BAR (BinAmphiphysinRvs)-domain.hich is required for their in vivo function and their ability to tubulate membranes . The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic.romatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise.eterodimerise or.n a few cases.nteract with small GTPases.
  IPR004148:BAR
InterPro domains unassigned to SynO:
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR004148:BAR 
Evalue:-94.958610534668 
Location:11-254IPR001452:SH3 
Evalue:-13.8239087409443 
Location:308-365
SequencesProtein: SHLB1_HUMAN (365 aa)
mRNA: AF257318 AF263293 NM_016009
Local Annotation
Synapse Ontology
endocytotic reaction via coated pits
sdb:0119 endocytotic reaction  (Evidence:domains)
clathrin-coat uncoating means clathrin was shed from the budding vesicle membrane.
sdb:0122 clathrin-coat uncoating  (Evidence:domains)
KO assignmentK00680
  Level 3 annotation:
    
  Level 2 annotation:
    Butanoate metabolism
    Glycerophospholipid metabolism
    Valine
     leucine and isoleucine degradation
    Lysine degradation
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    Limonene and pinene degradation
    Alkaloid biosynthesis II
    Ethylbenzene degradation
    Benzoate degradation via CoA ligation
    1- and 2-Methylnaphthalene degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 86943091-86943242Exon2: 49 residues, 86953994-86954136Exon3: 45 residues, 86957777-86957906Exon4: 46 residues, 86960810-86960944Exon5: 33 residues, 86962583-86962676Exon6: 32 residues, 86972872-86972962Exon7: 35 residues, 86973349-86973450Exon8: 78 residues, 86980478-86980707Exon9: 155 residues, 86981398-86981857Exon10: 2 residues, -Jump to SHLB1_HUMANExon1: 33 residues, 86943145-86943242Exon2: 49 residues, 86953994-86954136Exon3: 45 residues, 86957777-86957906Exon4: 46 residues, 86960810-86960944Exon5: 33 residues, 86962583-86962676Exon6: 32 residues, 86972872-86972962Exon7: 35 residues, 86973349-86973450Exon8: 78 residues, 86980478-86980707Exon9: 81 residues, 86981398-86981637Exon10: 2 residues, -Jump to SHLB1_HUMANExon1: 26 residues, 86943165-86943242Exon2: 49 residues, 86953994-86954136Exon3: 45 residues, 86957777-86957906Exon4: 46 residues, 86960810-86960944Exon5: 33 residues, 86962583-86962676Exon6: 15 residues, 86966673-86966712Exon7: 10 residues, 86968358-86968382Exon8: 32 residues, 86972872-86972962Exon9: 35 residues, 86973349-86973450Exon10: 78 residues, 86980478-86980707Exon11: 48 residues, 86981398-86981538Exon12: 2 residues, -Jump to SHLB1_HUMAN  
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