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0SGCA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSGCA
DescriptionAlpha-sarcoglycan precursor (alpha-sg) (adhalin) (50 kda dystrophin- associated glycoprotein) (50dag) (dystroglycan 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016010 dystrophin-associated glycoprotein complex (TAS)
0006936 muscle contraction (TAS)
0007517 muscle development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal.ardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle.he manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear . This family contains alpha and epsilon members.
  IPR008908:Sarcoglycan alphaepsilon
In animals.adherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at the domaindomain interface .
  IPR006644:Dystroglycan-type cadherin-like
IPR008908:Sarcoglycan_2 
Evalue:-222.119186401367 
Location:6-387
SequencesProtein: SGCA_HUMAN (387 aa)
mRNA: NM_000023
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 17 residues, 45598389-45598437Exon2: 42 residues, 45599727-45599847Exon3: 53 residues, 45599941-45600096Exon4: 26 residues, 45600306-45600379Exon5: 68 residues, 45600733-45600932Exon6: 56 residues, 45601451-45601614Exon7: 71 residues, 45602502-45602711Exon8: 11 residues, 45602999-45603026Exon9: 66 residues, 45607616-45607809Exon10: 74 residues, 45608071-45608288Exon11: 2 residues, -Jump to SGCA_HUMAN  
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Loci Cluster (Details)Loci: 4299 45545034-45562166 ~-17K 16176(-)Loci: 3018 45598389-45608288 ~-10K 16177(SGCA)(+)Loci: 4300 45800227-45805561 ~-5K 16185(MRPL27)(-)Loci: 3019 45965097-45975160 ~-10K 16195(EPN3)(+)Loci: 3020 45993447-46059430 ~-66K 16202(CACNA1G)(+)Loci: 3021 46067226-46124061 ~-57K 16218(ABCC3)(+)Loci: 3017 45527694-45543421 ~-16K 16175(PDK2)(+)Link out to UCSC