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0SFXN5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFXN5
DescriptionSideroflexin-5.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The MTC family consists of a limited number of homologues.ll from eukaryotes. One member of the family has been functionally characterized as a tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate.is-aconitate.hreo-D-isocitrate.- and L-tartrate.alate.uccinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. The rest of the characterized proteins appear to be sideroflexins involved in iron transport.
  IPR004686:Tricarboxylate/iron carrier
IPR004686:Mtc 
Evalue:-118.200660705566 
Location:32-340
SequencesProtein: SFXN5_HUMAN (340 aa)
mRNA: NM_144579
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1022 residues, 73022673-73025736Exon2: 41 residues, 73041767-73041885Exon3: 30 residues, 73049084-73049170Exon4: 40 residues, 73052206-73052322Exon5: 32 residues, 73068894-73068985Exon6: 24 residues, 73079585-73079651Exon7: 21 residues, 73081067-73081124Exon8: 20 residues, 73082161-73082215Exon9: 10 residues, 73100875-73100901Exon10: 20 residues, 73103158-73103213Exon11: 11 residues, 73103824-73103851Exon12: 28 residues, 73121490-73121568Exon13: 25 residues, 73139164-73139233Exon14: 79 residues, 73152240-73152473Exon15: 2 residues, -Jump to SFXN5_HUMAN  
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Loci Cluster (Details)Loci: 4447 73154018-73193653 ~-40K 20643(RAB11FIP5)(-)Loci: 4448 73371573-73374118 ~-3K 20647(EGR4)(-)Loci: 4446 73022673-73152473 ~-130K 20642(SFXN5)(-)Link out to UCSC