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0SFRS9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFRS9
DescriptionSplicing factor, arginine/serine-rich 9 (pre-mrna splicing factor srp30c).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006397 mRNA processing (TAS)
0006376 mRNA splice site selection (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-22.6382713317871 
Location:16-84IPR000504:RRM_1 
Evalue:-13.4685211181641 
Location:113-177
SequencesProtein: SFRS9_HUMAN (221 aa)
mRNA: NM_003769
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 166 residues, 119383853-119384348Exon2: 59 residues, 119386135-119386308Exon3: 55 residues, 119387812-119387973Exon4: 113 residues, 119391607-119391941Exon5: 2 residues, -Jump to SFRS9_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4079 119017288-119038982 ~-22K 9812(RAB35)(-)Loci: 4080 119132639-119187892 ~-55K 9820(PXN)(-)Loci: 2793 119360286-119362912 ~-3K 9830(COX6A1)(+)Loci: 4081 119383853-119391941 ~-8K 9835(SFRS9)(-)Loci: 2794 119392042-119420680 ~-29K 9836(DNCL1)(+)Loci: 2795 119572753-119589508 ~-17K 9842(CABP1)(+)Loci: 4078 118607977-118799478 ~-192K 9809(CIT)(-)Link out to UCSC