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0SFRS7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFRS7
DescriptionSplicing factor, arginine/serine-rich 7 (splicing factor 9g8).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005515 protein binding (IPI)
0006397 mRNA processing (TAS)
0008380 RNA splicing (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
The 18 residues CCHC zinc finger domain is mainly found in the Nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process . It is also found in eukaryotic proteins involved in RNA binding or single strand DNA binding.
  IPR001878:Zinc finger, CCHC-type
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-21.2076091766357 
Location:13-79IPR001878:zf-CCHC 
Evalue:-3.58502674102783 
Location:104-121
SequencesProtein: SFRS7_HUMAN (238 aa)
mRNA: NM_001031684
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 529 residues, 38824248-38825833Exon2: 14 residues, 38826789-38826825Exon3: 20 residues, 38827339-38827393Exon4: 39 residues, 38828692-38828803Exon5: 27 residues, 38829224-38829299Exon6: 61 residues, 38830174-38830351Exon7: 62 residues, 38830659-38830840Exon8: 45 residues, 38831874-38832005Exon9: 2 residues, -Jump to SFRS7_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4435 38824248-38832005 ~-8K 20300(SFRS7)(-)Loci: 4434 38644680-38683528 ~-39K 20297(HNRPLL)(-)Link out to UCSC