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0SFR15_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSplicing factor, arginine/serine-rich 15 (ctd-binding sr-like protein ra4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
RPR is a domain of unknown function present in proteins which are involved in regulation ofnuclear pre-mRNA.
  IPR006569:Regulation of nuclear pre-mRNA protein
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
SequencesProtein: SFR15_HUMAN (1147 aa)
mRNA: NM_020706
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 374 residues, 31965419-31966538Exon2: 66 residues, 31979232-31979424Exon3: 31 residues, 31979581-31979668Exon4: 57 residues, 31979751-31979917Exon5: 54 residues, 31982490-31982648Exon6: 54 residues, 31984980-31985137Exon7: 40 residues, 31986000-31986114Exon8: 35 residues, 31986532-31986633Exon9: 65 residues, 31987477-31987668Exon10: 30 residues, 31988387-31988473Exon11: 58 residues, 31988996-31989164Exon12: 38 residues, 31990296-31990405Exon13: 62 residues, 31990752-31990934Exon14: 61 residues, 31995178-31995355Exon15: 49 residues, 31995959-31996102Exon16: 47 residues, 31996427-31996563Exon17: 56 residues, 31997948-31998110Exon18: 17 residues, 31999606-31999651Exon19: 30 residues, 32000457-32000541Exon20: 97 residues, 32025846-32026133Exon21: 2 residues, -Jump to SFR15_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4547 31965419-32026133 ~-61K 23737(SFRS15)(-)Loci: 3284 31953805-31963112 ~-9K 23735(SOD1)(+)Link out to UCSC