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0SFR12_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSplicing factor, arginine/serine-rich 12 (serine-arginine-rich splicing regulatory protein 86) (srrp86) (splicing regulatory protein 508) (srrp508).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
SequencesProtein: SFR12_HUMAN (508 aa)
mRNA: NM_139168
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 65489710-65489814Exon2: 43 residues, 65490392-65490516Exon3: 40 residues, 65490802-65490918Exon4: 57 residues, 65493692-65493857Exon5: 61 residues, 65493997-65494176Exon6: 45 residues, 65495375-65495506Exon7: 40 residues, 65496366-65496481Exon8: 42 residues, 65501634-65501754Exon9: 123 residues, 65502168-65502531Exon10: 34 residues, 65506529-65506625Exon11: 50 residues, 65509097-65509242Exon12: 699 residues, 65510302-65512393Exon13: 2 residues, -Jump to SFR12_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3457 65053840-65155143 ~-101K 28898(NLN)(+)Loci: 3458 65258139-65412606 ~-154K 28902(ERBB2IP)(+)Loci: 3459 65489710-65512393 ~-23K 28906(SFRS12)(+)Loci: 4715 64921264-64955943 ~-35K 28891(TRIM23)(-)Link out to UCSC