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0SFPQ_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFPQ
DescriptionSplicing factor, proline-and glutamine-rich (polypyrimidine tract- binding protein-associated splicing factor) (ptb-associated splicing factor) (psf) (dna-binding p52/p100 complex, 100 kda subunit) (100-kda dna-pairing protein) (hpomp100).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0006397 mRNA processing (TAS)
0008380 RNA splicing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found C-terminal to 1 or 2 domains in NONA and PSP1 proteins.
  IPR012975:NOPS
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR012975:NOPS 
Evalue:-37.1191864013672 
Location:444-495IPR000504:RRM 
Evalue:-17.4089353929735 
Location:298-365IPR000504:RRM_1 
Evalue:-16.0809211730957 
Location:373-443
SequencesProtein: SFPQ_HUMAN (707 aa)
mRNA: NM_005066
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 331 residues, 35421789-35422781Exon2: 42 residues, 35425188-35425310Exon3: 18 residues, 35425390-35425439Exon4: 41 residues, 35426160-35426278Exon5: 30 residues, 35427190-35427275Exon6: 67 residues, 35427373-35427570Exon7: 34 residues, 35428685-35428781Exon8: 102 residues, 35428881-35429183Exon9: 65 residues, 35429528-35429717Exon10: 306 residues, 35430409-35431322Exon11: 2 residues, -Jump to SFPQ_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2506 34999364-35000514 ~-1K 1035(GJB4)(+)Loci: 2507 35019376-35024551 ~-5K 1036(GJB3)(+)Loci: 2508 35031185-35033933 ~-3K 1037(GJA4)(+)Loci: 3791 35421789-35431322 ~-10K 1048(SFPQ)(-)Loci: 2505 34993307-34996699 ~-3K 1034(GJB5)(+)Link out to UCSC