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0SERA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePHGDH
DescriptionD-3-phosphoglycerate dehydrogenase (ec 1.1.1.95) (3-pgdh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005489 electron transporter activity (TAS)
0004617 phosphoglycerate dehydrogenase activity (TAS)
0007420 brain development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. All contain a glycine-rich region located in the central section of these enzymes.his region corresponds to the NAD-binding domain. The catalytic domain is described in
  IPR006140:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. The catalytic domain contains a number of conserved charged residues which may play a role in the catalytic mechanism. The NAD-binding domain is described in
  IPR006139:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region
This group of sequences represent the long form of D-3-phosphoglycerate dehydrogenase.hey include the serA gene of one pathway of serine biosynthesis. Shorter forms not in this group include SerA from Escherichia coli.
  IPR006236:D-3-phosphoglycerate dehydrogenase
IPR006140:2-Hacid_dh_C 
Evalue:-78.7695541381836 
Location:110-284IPR001588:CASEIN_ALPHA_BETA 
Evalue:0 
Location:420-427
SequencesProtein: SERA_HUMAN (532 aa)
mRNA: NM_006623
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK00058
  Level 3 annotation:
    D-3-phosphoglycerate dehydrogenase
  Level 2 annotation:
    Glycine
     serine and threonine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 92 residues, 120056032-120056306Exon2: 52 residues, 120065315-120065467Exon3: 24 residues, 120067521-120067587Exon4: 20 residues, 120070996-120071051Exon5: 35 residues, 120071149-120071248Exon6: 46 residues, 120078779-120078912Exon7: 51 residues, 120079440-120079589Exon8: 53 residues, 120081259-120081412Exon9: 46 residues, 120084531-120084664Exon10: 45 residues, 120085912-120086043Exon11: 81 residues, 120086952-120087190Exon12: 111 residues, 120088031-120088359Exon13: 2 residues, -Jump to SERA_HUMAN  
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Loci Cluster (Details)Loci: 2544 120056032-120088359 ~-32K 2308(PHGDH)(+)Loci: 3825 120092527-120113041 ~-21K 2310(HMGCS2)(-)Loci: 3826 120255700-120413799 ~-158K 2313(NOTCH2)(-)Loci: 2543 119759295-119767172 ~-8K 2303(HSD3B2)(+)Link out to UCSC