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0SEM6A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSemaphorin 6a precursor (semaphorin via) (sema via) (semaphorin 6a-1) (sema6a-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030424 axon (NAS)
0016021 integral to membrane (NAS)
0005515 protein binding (IPI)
0006915 apoptosis (NAS)
0007411 axon guidance (NAS)
0007166 cell surface receptor linked signal transdu... (NAS)
0007010 cytoskeleton organization and biogenesis (NAS)
0007399 neurogenesis (NAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Sema domain occurs in semaphorins.hich are a large family of secreted and transmembrane proteins.ome of which function as repellent signals during axon guidance. Sema domains also occur in a hepatocyte growth factor receptor.n SEX protein and in viral proteins.CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA.D3 and CD2 induced T cell proliferation.ncreases CD45 induced T cell adhesion.nduces B cell homotypic adhesion and down-regulates B cell expression of CD23.The Sema domain is characterised by a conserved set of cysteine residues.hich form four disulfide bonds to stabilise the structure. The Sema domainfold is a variation of the beta propeller topology.ith seven blades radiallyarranged around a central axis. Each blade contains a four-stranded (strands A to D) antiparallel beta sheet. The inner strand of eachblade (A) lines the channel at the center of the propeller.ith strands B andC of the same repeat radiating outward.nd strand D of the next repeatforming the outer edge of the blade. The large size of the Sema domain is notdue to a single inserted domain but results from the presence of additionnalsecondary structure elements inserted in most of the blades. The Sema domainuses a loop and hook system to close the circle between the first and thelast blades. The blades are constructed sequentially with an N-terminal beta-strand closing the circle by providing the outermost strand (D) of the seventh(C-terminal) blade. The beta-propeller is further stabilized by an extensionof the N-terminus.roviding an additional.ifth beta-strand on the outeredge of blade 6 .CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at
  IPR001627:Semaphorin/CD100 antigen
This is a cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found in plexin () . Two copies of the repeat are found in mahogany protein. A related Caenorhabditis elegans protein () contains four copies of the repeat.hile the Met receptor contains a single copy of the repeat.
This is a domain that has been found in plexins.emaphorins and integrins. Plexin is involved in the development of neural and epithelial tissues; semaphorins induce the collapse and paralysis of neuronal growth cones; and integrins may mediate adhesive or migratory functions of epithelial cells.
This family includes inhibitors of proteinases and amylases.uch as trypsin inhibitors () .arboxypeptidase A inhibitors () .nd alpha-amylase inhibitors (AAI) . The proteins display a knottins-like (small inhibitors.oxins.ectins) disulphide-bound fold.ontaining a beta-hairpin with two adjacent disulphides.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.More information about this protein can be found at Protein of the Month: alpha-Amylase .
  IPR011052:Proteinase and amylase inhibitor
SequencesProtein: SEM6A_HUMAN (1030 aa)
mRNA: NM_020796
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK06842
  Level 3 annotation:
    semaphorin 6
  Level 2 annotation:
    CAM ligands
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1419 residues, 115807150-115811406Exon2: 57 residues, 115831177-115831342Exon3: 9 residues, 115836667-115836688Exon4: 21 residues, 115839139-115839198Exon5: 29 residues, 115841440-115841521Exon6: 49 residues, 115841608-115841749Exon7: 61 residues, 115842136-115842313Exon8: 54 residues, 115843716-115843872Exon9: 46 residues, 115846038-115846170Exon10: 74 residues, 115850343-115850561Exon11: 31 residues, 115851702-115851791Exon12: 42 residues, 115852482-115852602Exon13: 32 residues, 115855334-115855425Exon14: 36 residues, 115859007-115859109Exon15: 23 residues, 115859845-115859908Exon16: 22 residues, 115860921-115860982Exon17: 41 residues, 115865804-115865922Exon18: 48 residues, 115868439-115868577Exon19: 208 residues, 115937779-115938398Exon20: 2 residues, -Jump to SEM6A_HUMANExon1: 688 residues, 115809344-115811406Exon2: 57 residues, 115831177-115831342Exon3: 19 residues, 115836479-115836530Exon4: 9 residues, 115836667-115836688Exon5: 21 residues, 115839139-115839198Exon6: 29 residues, 115841440-115841521Exon7: 49 residues, 115841608-115841749Exon8: 61 residues, 115842136-115842313Exon9: 54 residues, 115843716-115843872Exon10: 46 residues, 115846038-115846170Exon11: 74 residues, 115850343-115850561Exon12: 31 residues, 115851702-115851791Exon13: 42 residues, 115852482-115852602Exon14: 32 residues, 115855334-115855425Exon15: 36 residues, 115859007-115859109Exon16: 23 residues, 115859845-115859908Exon17: 22 residues, 115860921-115860982Exon18: 41 residues, 115865804-115865922Exon19: 48 residues, 115868439-115868577Exon20: 72 residues, 115937779-115937990Exon21: 2 residues, -Jump to SEM6A_HUMAN  
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