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0SDF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSDF2
DescriptionStromal cell-derived factor 2 precursor (sdf-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (TAS)
0004169 dolichyl-phosphate-mannose-protein mannosyl... (TAS)
0006486 protein amino acid glycosylation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
This is a domain found in ryanodine.nositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1..-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules . The function is modulated by Ca2+.g2+.TP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) . protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.
  IPR003608:MIR
IPR003608:MIR 
Evalue:-14.7958800173441 
Location:83-138IPR003608:MIR 
Evalue:-10.2006594505464 
Location:21-75IPR003608:MIR 
Evalue:-10.0506099933551 
Location:140-193
SequencesProtein: SDF2_HUMAN (211 aa)
mRNA: NM_006923
Local Annotation
Synapse Ontology
Any process that activates or increases the rate, frequency or extent of synaptic growth at neuromuscular junction.
sdb:0047 positive regulation of synaptic growth at neuromuscular junction  (Evidence:domains)
those channels, like InsP3-gated calcium channels which activated by InsP3 and release calcium into plasma.
sdb:0117 ionotropic receptor on the ER  (Evidence:domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
activation of calmodulin-dependent protein kinases
sdb:0204 activation of calmodulin-dependent protein kinase  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
calcium dependent short-term forms of presynaptic plasticity
sdb:0234 calcium dependent short-term forms of presynaptic plasticity  (Evidence:domains)
intracellular calcium store release to change the concentration of cytosolic calcium.
sdb:0321 intracellular calcium store release  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 230 residues, 23999734-24000421Exon2: 67 residues, 24006431-24006628Exon3: 65 residues, 24012870-24013060Exon4: 2 residues, -Jump to SDF2_HUMAN  
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Loci Cluster (Details)Loci: 4275 23928711-23950183 ~-21K 15382(SPAG5)(-)Loci: 4276 23999734-24013060 ~-13K 15388(SDF2)(-)Loci: 4277 24065429-24069013 ~-4K 15393(RAB34)(-)Loci: 4274 23897851-23903770 ~-6K 15376(UNC119)(-)Link out to UCSC