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0SDF2L_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSDF2L1
DescriptionStromal cell-derived factor 2-like protein 1 precursor (sdf2-like protein 1) (pwp1-interacting protein 8).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
This is a domain found in ryanodine.nositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1..-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules . The function is modulated by Ca2+.g2+.TP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) . protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.
  IPR003608:MIR
IPR003608:MIR 
Evalue:-13.2146701649892 
Location:95-150IPR003608:MIR 
Evalue:-10.0705810742857 
Location:33-87IPR003608:MIR 
Evalue:-3.88605664769316 
Location:151-205IPR000886:ER_TARGET 
Evalue:0 
Location:218-221
SequencesProtein: SDF2L_HUMAN (221 aa)
mRNA: NM_022044
Local Annotation
Synapse Ontology
Any process that activates or increases the rate, frequency or extent of synaptic growth at neuromuscular junction.
sdb:0047 positive regulation of synaptic growth at neuromuscular junction  (Evidence:domains)
those channels, like InsP3-gated calcium channels which activated by InsP3 and release calcium into plasma.
sdb:0117 ionotropic receptor on the ER  (Evidence:domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
activation of calmodulin-dependent protein kinases
sdb:0204 activation of calmodulin-dependent protein kinase  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
calcium dependent short-term forms of presynaptic plasticity
sdb:0234 calcium dependent short-term forms of presynaptic plasticity  (Evidence:domains)
intracellular calcium store release to change the concentration of cytosolic calcium.
sdb:0321 intracellular calcium store release  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 91 residues, 20326541-20326812Exon2: 67 residues, 20327150-20327347Exon3: 137 residues, 20328182-20328587Exon4: 2 residues, -Jump to SDF2L_HUMAN  
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Loci Cluster (Details)Loci: 3301 20326541-20328587 ~-2K 24274(SDF2L1)(+)Loci: 4561 20443948-20551970 ~-108K 24279(MAPK1)(-)Loci: 3300 20251956-20308323 ~-56K 24268(UBE2L3)(+)Link out to UCSC