SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0SCYBE_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCXCL14
DescriptionSmall inducible cytokine b14 precursor (cxcl14) (chemokine brak).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008009 chemokine activity (TAS)
0007267 cell-cell signaling (TAS)
0006935 chemotaxis (TAS)
0007165 signal transduction (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/899121388.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Most members of this family of low-molecular weight proteins seem to havemitogenic.hemotactic or inflammatory activities. They are released by phagocytes.esenchymal cells and a wide variety of tissue cells.pon exposure to inflammation. These small cytokines are also called intercrines or chemokines. Theyare cationic proteins of 70 to 100 amino acid residues that share four conservedcysteine residues involved in two disulphide bonds.The family can be split into two groups.epending on the spacing of two N-terminalCys residues: in one group (CxC).he cysteines are separated by asingle amino acid; in the second (CC).hey are adjacent . The CxCgroup includes such factors as interleukin-8.latelet factor 4.elanoma growthstimulatory activity protein.acrophage inflammatory protein 2.latelet basicprotein.nd several others. The C-C group includes the monocyte chemotacticproteins.acrophage inflammatory proteins and others.The accumulation of neutrophil leukocytes in tissues is a major event in inflammation. defensive reaction in response to injury or infection . Neutrophils are drawn in from the blood by chemotactic signals that direct their migration to the affected site. Interleukin-8 (IL8) is one such chemotactic protein: it is released by phagocytes.esenchymal cells and a wide variety of tissue cells.pon exposure to inflammation; and it acts as a neutrophil-activating cytokine.nducing chemotaxis.xo- cytosis.nd the respiratory burst.
  IPR002473:Small chemokine, C-X-C/Interleukin 8
IPR002473:INTERLEUKIN8 
Evalue:0 
Location:40-63IPR001089:SMALL_CYTOKINES_CXC 
Evalue:0 
Location:0-0
SequencesProtein: SCYBE_HUMAN (99 aa)
mRNA: BC003513 NM_004887
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 395 residues, 134934274-134935457Exon2: 40 residues, 134938160-134938274Exon3: 37 residues, 134942022-134942128Exon4: 190 residues, 134942303-134942868Exon5: 2 residues, -Jump to SCYBE_HUMANExon1: 28 residues, 134935374-134935457Exon2: 40 residues, 134938160-134938274Exon3: 37 residues, 134942022-134942128Exon4: 88 residues, 134942303-134942561Exon5: 2 residues, -Jump to SCYBE_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3478 135198314-135252223 ~-54K 29444(+)Loci: 4728 134934274-134942868 ~-9K 29440(CXCL14)(-)Link out to UCSC