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0SCOT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOXCT1
DescriptionSuccinyl-coa:3-ketoacid-coenzyme a transferase 1, mitochondrial precursor (ec 2.8.3.5) (somatic-type succinyl coa:3-oxoacid coa- transferase) (scot-s).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008260 3-oxoacid CoA-transferase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Coenzyme A (CoA) transferases belong to an evolutionary conserved .amily of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits.
  IPR004165:Coenzyme A transferase
CoA-transferases catalyse the reversible transfer of of coenzyme A from CoA-thioesters to free acids.nd can be divided into three families . Family I includes transferases for 3-oxoacids (..hort-chain fatty acids (. and glutaconate (). Most of the family I enzymes use acetyl-CoA or succinyl-CoA as CoA donors.nd are composed of two separate polypeptides.ubunits A and B.hich generally aggregate as heterodimers or heterotetramers. The eukaryotic enzymes.owever.re generally composed of a single two-domain polypetide representing a fusion of the A and B subunits. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme .This entry represents the B subunit of family I CoA-transferases.hich contains the conserved active-site glutamate residue. This domain forms a three-layer alpha-beta-alpha sandwich where the central layer is a mixed beta-sheet.gainst which helices pack from both sides . The active site is thought to be located at the interface of the A and B subunits and formed by loops from both subunits.
  IPR012791:3-oxoacid CoA-transferase, subunit B
CoA-transferases catalyse the reversible transfer of of coenzyme A from CoA-thioesters to free acids.nd can be divided into three families . Family I includes transferases for 3-oxoacids (..hort-chain fatty acids (. and glutaconate (). Most of the family I enzymes use acetyl-CoA or succinyl-CoA as CoA donors.nd are composed of two separate polypeptides.ubunits A and B.hich generally aggregate as heterodimers or heterotetramers. The eukaryotic enzymes.owever.re generally composed of a single two-domain polypetide representing a fusion of the A and B subunits. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme .This entry represents the CoA-binding A subunit of family I CoA-transferases. This domain forms a three-layer alpha-beta-alpha sandwich where the central layer is an all parallel beta-sheet.gainst which helices pack from both sides . The active site is thought to be located at the interface of the A and B subunits and formed by loops from both subunits.
  IPR012792:3-oxoacid CoA-transferase, subunit A
IPR004165:CoA_trans 
Evalue:-112.376747131348 
Location:43-272IPR004165:CoA_trans 
Evalue:-74.1938171386719 
Location:302-501
SequencesProtein: SCOT_HUMAN (520 aa)
mRNA: NM_000436
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01028
  Level 3 annotation:
    3-oxoacid CoA-transferase subunit A
  Level 2 annotation:
    Butanoate metabolism
    Synthesis and degradation of ketone bodies
    Valine
     leucine and isoleucine degradation
K01029
  Level 3 annotation:
    3-oxoacid CoA-transferase subunit B
  Level 2 annotation:
    Butanoate metabolism
    Synthesis and degradation of ketone bodies
    Valine
     leucine and isoleucine degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 569 residues, 41765924-41767629Exon2: 36 residues, 41775248-41775350Exon3: 29 residues, 41785385-41785466Exon4: 32 residues, 41797969-41798059Exon5: 27 residues, 41829861-41829937Exon6: 26 residues, 41830535-41830608Exon7: 18 residues, 41836880-41836929Exon8: 33 residues, 41838927-41839022Exon9: 40 residues, 41841425-41841540Exon10: 38 residues, 41843189-41843297Exon11: 22 residues, 41876309-41876370Exon12: 37 residues, 41878533-41878640Exon13: 52 residues, 41885888-41886038Exon14: 47 residues, 41889277-41889413Exon15: 32 residues, 41897172-41897263Exon16: 38 residues, 41898500-41898609Exon17: 75 residues, 41906139-41906360Exon18: 2 residues, -Jump to SCOT_HUMAN  
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