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0SCFD1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSec1 family domain containing protein 1 (syntaxin binding protein 1- like 2) (sly1p).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis . They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation. protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events.heir interaction with syntaxin molecules seems to represent a negative regulatory step in secretion .
  IPR001619:Sec1-like protein
SequencesProtein: SCFD1_HUMAN (641 aa)
mRNA: NM_016106
Local Annotation
Synapse Ontology
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 29 residues, 30161271-30161356Exon2: 25 residues, 30167165-30167236Exon3: 31 residues, 30169433-30169522Exon4: 32 residues, 30172903-30172994Exon5: 43 residues, 30177081-30177204Exon6: 31 residues, 30178733-30178821Exon7: 32 residues, 30182272-30182362Exon8: 20 residues, 30188484-30188540Exon9: 30 residues, 30189521-30189607Exon10: 35 residues, 30192445-30192545Exon11: 48 residues, 30209212-30209352Exon12: 32 residues, 30212213-30212304Exon13: 26 residues, 30212880-30212954Exon14: 29 residues, 30213940-30214022Exon15: 34 residues, 30233729-30233826Exon16: 25 residues, 30239144-30239215Exon17: 28 residues, 30241252-30241332Exon18: 23 residues, 30244779-30244842Exon19: 27 residues, 30246946-30247022Exon20: 20 residues, 30254880-30254934Exon21: 19 residues, 30258281-30258334Exon22: 13 residues, 30260840-30260874Exon23: 24 residues, 30261450-30261516Exon24: 25 residues, 30273746-30273815Exon25: 77 residues, 30274542-30274769Exon26: 2 residues, -Jump to SCFD1_HUMAN  
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Loci Cluster (Details)Loci: 2829 30564624-30632385 ~-68K 10990(+)Loci: 2828 30161271-30274769 ~-113K 10985(SCFD1)(+)Link out to UCSC