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0SC6A9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A9
DescriptionSodium- and chloride-dependent glycine transporter 1 (glyt1) (glyt-1) (solute carrier family 6 member 9).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0015375 sodium symporter activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .Glycine is known to serve two contrasting roles as a neurotransmitter inthe central nervous system. Firstly.t serves as an inhibitoryneurotransmitter in the spinal cord.rainstem and retina.here it activates aligand-gated Cl- channel. Secondly.t is an obligatory co-agonist foractivation of the N-methyl-D-aspartate (NMDA) receptor - unless glycineis also bound to the NMDA receptor.lutamate cannot activate this ionchannel. Not surprisingly.hen.lasma membranes possess glycinetransporters in order to regulate its concentration. Two independent geneshave been identified that encode Na+ and Cl- -coupled glycine transporters.Their products.eferred to as GLYT-1 and GLYT-2.ave differingdistribution patterns within the central nervous system.uggesting theymay subserve unique functions . Indeed the distribution of the GLYT-1transporter suggests it may play a role in regulating glycineconcentrations in brain regions containing glycine-dependent NMDA receptors. Three different mRNA isoforms for GLYT-1 have been detected. Thesearise as a result of differential splicing.r the usage of multiplepromoter sites. They encode transporters of 633.38 and 692 amino acidresidues.ll three having 50-60% similarity to other transporters in theNa+ and Cl- -coupled neurotransmitter transporter superfamily.
  IPR003028:Glycine neurotransmitter transporter, type 1
IPR000175:SNF 
Evalue:-1e+125 
Location:86-636IPR003028:GLY1TRNSPORT 
Evalue:0 
Location:70-83
SequencesProtein: SC6A9_HUMAN (692 aa)
mRNA: NM_201649
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
?
sdb:0145 regulation of uptake of transmitters  (Evidence:keywords,domains)
?
sdb:0297 NMDA receptor  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05042
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, glycine), member 9
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 419 residues, 44234742-44235998Exon2: 59 residues, 44236113-44236284Exon3: 35 residues, 44239025-44239126Exon4: 35 residues, 44239214-44239314Exon5: 47 residues, 44239422-44239557Exon6: 81 residues, 44239648-44239886Exon7: 36 residues, 44240571-44240675Exon8: 47 residues, 44240770-44240905Exon9: 46 residues, 44241111-44241244Exon10: 92 residues, 44246611-44246882Exon11: 46 residues, 44248223-44248355Exon12: 54 residues, 44248984-44249141Exon13: 56 residues, 44249819-44249981Exon14: 95 residues, 44255305-44255584Exon15: 2 residues, -Jump to SC6A9_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2511 44217452-44229426 ~-12K 1299(B4GALT2)(+)Loci: 3798 44234742-44255584 ~-21K 1302(SLC6A9)(-)Loci: 2512 44451711-44458938 ~-7K 1306(DMAP1)(+)Loci: 2510 43888424-43943725 ~-55K 1275(JMJD2A)(+)Link out to UCSC