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0SC6A7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSodium-dependent proline transporter (solute carrier family 6 member 7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0015824 L-proline transport (TAS)
0007268 synaptic transmission (IPI)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
SequencesProtein: SC6A7_HUMAN (636 aa)
mRNA: NM_014228
Local Annotation
Synapse Ontology
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05040
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 135 residues, 149549712-149550116Exon2: 63 residues, 149554483-149554667Exon3: 46 residues, 149556471-149556603Exon4: 80 residues, 149556797-149557032Exon5: 48 residues, 149558983-149559122Exon6: 47 residues, 149560844-149560979Exon7: 36 residues, 149562102-149562206Exon8: 43 residues, 149562334-149562459Exon9: 39 residues, 149563422-149563535Exon10: 46 residues, 149563662-149563794Exon11: 35 residues, 149564287-149564387Exon12: 35 residues, 149564582-149564683Exon13: 58 residues, 149565211-149565379Exon14: 557 residues, 149569161-149570827Exon15: 2 residues, -Jump to SC6A7_HUMAN  
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Loci Cluster (Details)Loci: 4743 149563423-149649529 ~-86K 29756(CAMK2A)(-)Loci: 4744 149656101-149662641 ~-7K 29760(ARSI)(-)Loci: 3502 149960834-150012089 ~-51K 29771(SYNPO)(+)Loci: 4745 150068502-150118769 ~-50K 29777(DCTN4)(-)Loci: 3501 149549712-149570827 ~-21K 29755(SLC6A7)(+)Link out to UCSC