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0SC6A6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A6
DescriptionSodium- and chloride-dependent taurine transporter.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005369 sodium symporter activity (TAS)
0006520 amino acid metabolism (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .Cells regulate their volume and adapt to alterations in the tonicity oftheir local environment by adjusting their solute content accordingly.Resultant water movements rapidly establish osmotic balance. Solutesutilised in this manner are referred to as osmolytes and include:glycerophosphorylcholine.etaine.yo-inositol.orbitol and taurine .Cell membrane transporters for betaine and taurine have been cloned.nd bysequence similarity they have been shown to belong to the Na+ and Cl--coupled neurotransmitter transporter superfamily. The taurine transporterhas a predicted length of ~620 amino acids and can also transportbeta-alanine. It has been found to be widely distributed in the body.ithtranscripts being detected in the kidney (high abundance).leal mucosa.iver.eart and in several regions of the brain including: the corpuscallosum.triatum and anterior commisure. Functional studies haverevealed that taurine transporter activity is regulated by hypertonicity.nd this regulation appears to occur at the level of mRNA accumulation .
  IPR002434:Taurine transporter
IPR000175:SNF 
Evalue:-1e+125 
Location:41-582IPR002434:TAUTRANSPORT 
Evalue:0 
Location:602-611IPR002434:TAUTRANSPORT 
Evalue:0 
Location:612-620
SequencesProtein: SC6A6_HUMAN (620 aa)
mRNA: NM_003043
Local Annotation
Synapse Ontology
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05039
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, taurine), member 6
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 84 residues, 14419109-14419359Exon2: 16 residues, 14432923-14432965Exon3: 82 residues, 14460135-14460375Exon4: 47 residues, 14462228-14462363Exon5: 80 residues, 14464093-14464328Exon6: 46 residues, 14474461-14474594Exon7: 47 residues, 14483027-14483162Exon8: 36 residues, 14484364-14484468Exon9: 43 residues, 14484599-14484724Exon10: 39 residues, 14488716-14488829Exon11: 48 residues, 14493716-14493854Exon12: 36 residues, 14494977-14495080Exon13: 35 residues, 14495596-14495697Exon14: 59 residues, 14498182-14498353Exon15: 867 residues, 14501378-14503973Exon16: 2 residues, -Jump to SC6A6_HUMAN  
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