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0SC6A3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A3
DescriptionSodium-dependent dopamine transporter (da transporter) (dat).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0016021 integral to membrane (TAS)
0005886 plasma membrane (IDA)
0005329 dopamine transporter activity (TAS)
0005515 protein binding (IPI)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .In the mammalian brain.he dopamine system is thought to be involved inthe control of locomotion.ognition and endocrine function. The dopaminetransporter is critical for the removal of dopamine from the extracellularspace.ollowing its release.nd is the principal site of action forpsycho-stimulant drugs.uch as cocaine and amphetamines.hich inhibitthe transporters activity. A single form of dopamine transporter(containing ~620 amino acids) has been isolated from humans and othermammals. Studies of its brain distribution show transcripts to be presentin areas previously established to possess dopaminergic systems.uch asthe substantia nigra and ventral tegmental area.hich regions are knownto contain dopaminergic cell bodies . Targeted gene disruption of thedopamine transporter has confirmed its importance in maintaining lowextracellular dopamine levels. Mice lacking the transporter show profoundalterations in the homeostasis of the nigrostriatal dopamine system of thebrain. Extracellular levels of dopamine are elevated and removal ofreleased dopamine is ~300 times slower then in control mice. Additionally.he rather stereotyped behavioural responses observed in response toadministration of cocaine or amphetamine are greatly attenuated .
  IPR002436:Dopamine neurotransmitter transporter
IPR000175:SNF 
Evalue:-1e+125 
Location:60-597IPR002436:DOPTRANSPORT 
Evalue:0 
Location:42-59IPR002436:DOPTRANSPORT 
Evalue:0 
Location:1-16IPR002436:DOPTRANSPORT 
Evalue:0 
Location:17-30
SequencesProtein: SC6A3_HUMAN (620 aa)
mRNA: NM_001044
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05036
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 656 residues, 1445908-1447873Exon2: 26 residues, 1454029-1454101Exon3: 58 residues, 1456036-1456204Exon4: 35 residues, 1459302-1459403Exon5: 35 residues, 1462140-1462240Exon6: 45 residues, 1462835-1462964Exon7: 39 residues, 1464357-1464470Exon8: 43 residues, 1467805-1467930Exon9: 36 residues, 1469212-1469316Exon10: 47 residues, 1473683-1473818Exon11: 48 residues, 1474990-1475129Exon12: 80 residues, 1485578-1485813Exon13: 46 residues, 1494473-1494605Exon14: 112 residues, 1496026-1496357Exon15: 29 residues, 1498462-1498543Exon16: 2 residues, -Jump to SC6A3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4703 713890-746421 ~-33K 28538(-)Loci: 4704 1103499-1165150 ~-62K 28551(SLC12A7)(-)Loci: 3442 1278469-1299303 ~-21K 28553(SLC6A18)(+)Loci: 4705 1445908-1498543 ~-53K 28561(SLC6A3)(-)Loci: 3441 271446-309792 ~-38K 28525(SDHA)(+)Link out to UCSC