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0SC6A2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A2
DescriptionSodium-dependent noradrenaline transporter (norepinephrine transporter) (net).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0005334 sodium symporter activity (TAS)
0005515 protein binding (IPI)
0007268 synaptic transmission (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .The human noradrenaline transporter is the primary target forwidely-used tricyclic antidepressant drugs.uch as desipramine. Cloning studieshave revealed a single noradrenaline transporter isoform. The cDNA sequencepredicts a protein of ~617 amino acids.ith 12-13 highly hydrophobicregions.s would be expected for a member of the Na+ and Cl- -coupledneurotransmitter superfamily . Related noradrenaline transporter specieshave been identified in both Drosophila and bullfrog. In mammalian species.RNA for the transporter is localised to the brainstem and the adrenalglands. Chromosome mapping has placed the encoding gene to chromosome16q12.2 in humans . Recently. bovine noradrenaline transporter varianthas been identified that shows altered targeting to the plasma membrane.This has implicated the cytoplasmic facing C-terminus in the intracellulartrafficking of this protein .
  IPR002435:Noradrenaline neurotransmitter transporter
IPR000175:SNF 
Evalue:-1e+125 
Location:56-594
SequencesProtein: SC6A2_HUMAN (617 aa)
mRNA: NM_001043
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05035
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 109 residues, 54248056-54248381Exon2: 46 residues, 54260977-54261109Exon3: 81 residues, 54263350-54263588Exon4: 48 residues, 54276555-54276694Exon5: 47 residues, 54283330-54283465Exon6: 36 residues, 54285422-54285526Exon7: 43 residues, 54286690-54286815Exon8: 39 residues, 54287637-54287750Exon9: 45 residues, 54289309-54289438Exon10: 35 residues, 54289881-54289981Exon11: 35 residues, 54290966-54291067Exon12: 58 residues, 54291551-54291719Exon13: 26 residues, 54293275-54293347Exon14: 490 residues, 54293735-54295199Exon15: 2 residues, -Jump to SC6A2_HUMAN  
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Loci Cluster (Details)Loci: 4225 54394266-54424576 ~-30K 14117(CES1)(-)Loci: 2940 54248056-54295199 ~-47K 14116(SLC6A2)(+)Link out to UCSC