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0SC5A7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC5A7
DescriptionHigh-affinity choline transporter 1 (solute carrier family 5 member 7) (hemicholinium-3-sensitive choline transporter) (cht).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IDA)
0015220 choline transporter activity (IMP)
0008292 acetylcholine biosynthesis (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. Thereby theenergy stored in an inwardly directed electrochemical sodium gradient (sodium motive force.MF) is used to drive solute accumulation against a concentrationgradient. The SMF is generated by primary sodium pumps (e.g. sodium/potassium ATPases.odium translocating respiratory chain complexes) or via the action ofsodium/proton antiporters. Sodium/substrate transporters are grouped in different families based on sequence similarities . One of these families.nown as the sodium:solute symporter family (SSSF).ontains over a hundred members of pro- and eukaryotic origin . The average hydropathy plot for SSSF proteins predicts 11 to 15 putative transmembrane domains (TMs) in alpha-helical conformation. A secondary structure model of PutP from Escherichia coli suggests the protein contains 13 TMs with the N-terminus locatedon the periplasmic side of the membrane and the C-terminus facing the cytoplasm. The results support the idea of a common topological motif for members of the SSSF. Transporters with a C-terminal extension are proposed to havean additional 14th TM. An ordered binding model of sodium/substrate transport suggests that sodium binds tothe empty transporter first.hereby inducing a conformational alteration which increases the affinity of the transporter for the solute. The formation of the ternarycomplex induces another structural change that exposes sodium and substrate to the other site of the membrane. Substrate and sodium are released and the emptytransporter re-orientates in the membrane allowing the cycle to start again.
  IPR001734:Na+/solute symporter
IPR001734:SSF 
Evalue:-9.08618640899658 
Location:42-442IPR001734:NA_SOLUT_SYMP_1 
Evalue:0 
Location:0-0
SequencesProtein: SC5A7_HUMAN (580 aa)
mRNA: NM_021815
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 76 residues, 107969426-107969651Exon2: 78 residues, 107970992-107971221Exon3: 40 residues, 107974993-107975107Exon4: 54 residues, 107975859-107976015Exon5: 51 residues, 107980725-107980874Exon6: 50 residues, 107984784-107984928Exon7: 53 residues, 107988936-107989090Exon8: 74 residues, 107991352-107991570Exon9: 1252 residues, 107993119-107996871Exon10: 2 residues, -Jump to SC5A7_HUMAN  
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Loci Cluster (Details)Loci: 3182 108271526-108292802 ~-21K 21050(SULT1C1)(+)Loci: 3183 108360852-108370702 ~-10K 21052(SULT1C2)(+)Loci: 3184 108432067-108492285 ~-60K 21053(GCC2)(+)Loci: 3181 107969426-107996871 ~-27K 21048(SLC5A7)(+)Link out to UCSC