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0SC11A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSCN11A
DescriptionSodium channel protein type xi alpha subunit (voltage-gated sodium channel alpha subunit nav1.9) (sensory neuron sodium channel 2) (peripheral nerve sodium channel 5) (hnan).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005248 voltage-gated sodium channel activity (TAS)
0042493 response to drug (TAS)
0006814 sodium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this entry contain a region found exclusively in eukaryotic sodium channels or their subunits.any of which are voltage-gated. Members very often also contain between one and four copies of and.ess often.ne copy of .
  IPR010526:Sodium ion transport-associated
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Voltage-dependent sodium channels are transmembrane (TM) proteinsresponsible for the depolarising phase of the action potential in mostelectrically excitable cells . They may exist in 3 states : theresting state.here the channel is closed; the activated state.here thechannel is open; and the inactivated state.here the channel is closedand refractory to opening. Several different structurally and functionallydistinct isoforms are found in mammals.oded for by a multigene family.hese being responsible for the different types of sodium ion currentsfound in excitable tissues.The structure of sodium channels is based on 4 internal repeats of a 6-helixbundle (in which 5 of the membrane-spanning segments are hydrophobic andthe other is positively charged).orming a 24-helical bundle. The chargedsegments are believed to be localised within clusters formed by their 5 hydrophobic neighbours: it is postulated that the charged domain may be thevoltage sensor region.ossibly moving outward on depolarisation.ausing aconformational change. This model.roposed by Noda et al. .ontrastswith that of Sato and Matsumoto .n which the TM segments are juxtaposedoctagonally. The basic structural motif (the 6-helix bundle) is also found in potassium and calcium channel alpha subunits.Cation channels are transport proteins responsible for the movement of cations through the membrane. These proteins contain 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times.hereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
  IPR001696:Na+ channel
IPR010526:Na_trans_assoc 
Evalue:-197.187088012695 
Location:824-1066IPR005821:Ion_trans 
Evalue:-68.0087738037109 
Location:1092-1307IPR005821:Ion_trans 
Evalue:-67.3565444946289 
Location:161-399IPR005821:Ion_trans 
Evalue:-58.6575775146484 
Location:1400-1603IPR005821:Ion_trans 
Evalue:-55.1023712158203 
Location:611-810IPR001696:NACHANNEL 
Evalue:0 
Location:1621-1634
SequencesProtein: SC11A_HUMAN (1791 aa)
mRNA: NM_014139
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK04843
  Level 3 annotation:
    sodium channel, voltage-gated, type XI, alpha
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 659 residues, 38862263-38864237Exon2: 92 residues, 38866975-38867246Exon3: 37 residues, 38879689-38879794Exon4: 48 residues, 38883815-38883953Exon5: 20 residues, 38887185-38887239Exon6: 90 residues, 38887939-38888203Exon7: 36 residues, 38888687-38888789Exon8: 60 residues, 38896444-38896618Exon9: 53 residues, 38899727-38899882Exon10: 40 residues, 38901782-38901897Exon11: 40 residues, 38902619-38902733Exon12: 146 residues, 38911027-38911459Exon13: 129 residues, 38913339-38913720Exon14: 62 residues, 38916388-38916568Exon15: 81 residues, 38920359-38920598Exon16: 45 residues, 38921686-38921816Exon17: 60 residues, 38924443-38924617Exon18: 68 residues, 38925491-38925689Exon19: 49 residues, 38926560-38926702Exon20: 24 residues, 38936429-38936496Exon21: 62 residues, 38937570-38937750Exon22: 33 residues, 38941909-38942004Exon23: 45 residues, 38943297-38943426Exon24: 35 residues, 38961905-38962005Exon25: 42 residues, 38963281-38963402Exon26: 157 residues, 38966590-38967056Exon27: 2 residues, -Jump to SC11A_HUMAN  
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Loci Cluster (Details)Loci: 4592 38024010-38046119 ~-22K 25407(PLCD1)(-)Loci: 3348 38182029-38271982 ~-90K 25418(OXSR1)(+)Loci: 4593 38564557-38666167 ~-102K 25429(SCN5A)(-)Loci: 4594 38713841-38810505 ~-97K 25434(SCN10A)(-)Loci: 4595 38862263-38967056 ~-105K 25435(SCN11A)(-)Loci: 3347 38004533-38023679 ~-19K 25403(VILL)(+)Link out to UCSC