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0SC10A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSCN10A
DescriptionSodium channel protein type x alpha subunit (voltage-gated sodium channel alpha subunit nav1.8) (peripheral nerve sodium channel 3) (hpn3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005245 voltage-gated calcium channel activity (TAS)
0007600 sensory perception (TAS)
0006814 sodium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this entry contain a region found exclusively in eukaryotic sodium channels or their subunits.any of which are voltage-gated. Members very often also contain between one and four copies of and.ess often.ne copy of .
  IPR010526:Sodium ion transport-associated
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Voltage-dependent sodium channels are transmembrane (TM) proteinsresponsible for the depolarising phase of the action potential in mostelectrically excitable cells . They may exist in 3 states : theresting state.here the channel is closed; the activated state.here thechannel is open; and the inactivated state.here the channel is closedand refractory to opening. Several different structurally and functionallydistinct isoforms are found in mammals.oded for by a multigene family.hese being responsible for the different types of sodium ion currentsfound in excitable tissues.The structure of sodium channels is based on 4 internal repeats of a 6-helixbundle (in which 5 of the membrane-spanning segments are hydrophobic andthe other is positively charged).orming a 24-helical bundle. The chargedsegments are believed to be localised within clusters formed by their 5 hydrophobic neighbours: it is postulated that the charged domain may be thevoltage sensor region.ossibly moving outward on depolarisation.ausing aconformational change. This model.roposed by Noda et al. .ontrastswith that of Sato and Matsumoto .n which the TM segments are juxtaposedoctagonally. The basic structural motif (the 6-helix bundle) is also found in potassium and calcium channel alpha subunits.Cation channels are transport proteins responsible for the movement of cations through the membrane. These proteins contain 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times.hereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
  IPR001696:Na+ channel
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR010526:Na_trans_assoc 
Evalue:-106.167488098145 
Location:904-1162IPR005821:Ion_trans 
Evalue:-71.5528411865234 
Location:155-396IPR005821:Ion_trans 
Evalue:-66.8860549926758 
Location:1188-1417IPR005821:Ion_trans 
Evalue:-57.4814872741699 
Location:1510-1721IPR005821:Ion_trans 
Evalue:-55.8239097595215 
Location:699-889IPR001696:NACHANNEL 
Evalue:0 
Location:1739-1752IPR000048:IQ 
Evalue:0 
Location:0-0IPR000048:IQ 
Evalue:0.0791812464594841 
Location:1852-1872
SequencesProtein: SC10A_HUMAN (1956 aa)
mRNA: NM_006514
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK04842
  Level 3 annotation:
    sodium channel, voltage-gated, type X, alpha
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 406 residues, 38713841-38715057Exon2: 92 residues, 38718333-38718604Exon3: 37 residues, 38723773-38723878Exon4: 48 residues, 38725972-38726110Exon5: 20 residues, 38727338-38727392Exon6: 97 residues, 38728655-38728940Exon7: 43 residues, 38730452-38730575Exon8: 60 residues, 38735147-38735321Exon9: 53 residues, 38738752-38738907Exon10: 43 residues, 38739924-38740048Exon11: 49 residues, 38741668-38741809Exon12: 151 residues, 38743100-38743547Exon13: 122 residues, 38745036-38745396Exon14: 60 residues, 38756009-38756183Exon15: 81 residues, 38758785-38759024Exon16: 39 residues, 38766567-38766679Exon17: 100 residues, 38768713-38769007Exon18: 59 residues, 38772282-38772453Exon19: 68 residues, 38773168-38773366Exon20: 49 residues, 38773512-38773654Exon21: 24 residues, 38777175-38777242Exon22: 66 residues, 38777686-38777878Exon23: 32 residues, 38779999-38780091Exon24: 45 residues, 38787773-38787902Exon25: 29 residues, 38805450-38805531Exon26: 41 residues, 38808544-38808663Exon27: 92 residues, 38810235-38810505Exon28: 2 residues, -Jump to SC10A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4592 38024010-38046119 ~-22K 25407(PLCD1)(-)Loci: 3348 38182029-38271982 ~-90K 25418(OXSR1)(+)Loci: 4593 38564557-38666167 ~-102K 25429(SCN5A)(-)Loci: 4594 38713841-38810505 ~-97K 25434(SCN10A)(-)Loci: 4595 38862263-38967056 ~-105K 25435(SCN11A)(-)Loci: 3347 38004533-38023679 ~-19K 25403(VILL)(+)Link out to UCSC