SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0SALL3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSALL3
DescriptionSal-like protein 3 (zinc finger protein sall3) (hsall3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR007087:zf-C2H2 
Evalue:-5.79587984085083 
Location:1141-1163IPR007087:zf-C2H2 
Evalue:-5.69896984100342 
Location:1113-1135IPR007087:zf-C2H2 
Evalue:-5.50863838195801 
Location:707-729IPR007087:zf-C2H2 
Evalue:-5.15490198135376 
Location:448-470IPR007087:zf-C2H2 
Evalue:-5.10237312316894 
Location:739-761IPR007087:zf-C2H2 
Evalue:-3.56863617897034 
Location:1005-1027IPR007087:zf-C2H2 
Evalue:-3.17392516136169 
Location:420-442IPR007087:zf-C2H2 
Evalue:-2.38721609115601 
Location:977-999IPR007087:ZINC_FINGER_C2H2_2 
Evalue:0 
Location:679-706IPR007087:ZnF_C2H2 
Evalue:2.39794000867204 
Location:51-71
SequencesProtein: SALL3_HUMAN (1300 aa)
mRNA: NM_171999
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 74841262-74841344Exon2: 1131 residues, 74853061-74856450Exon3: 435 residues, 74857878-74859179Exon4: 2 residues, -Jump to SALL3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3074 74930384-75239268 ~-309K 17451(ATP9B)(+)Loci: 3073 74841262-74859179 ~-18K 17450(SALL3)(+)Link out to UCSC