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0S6A18_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A18
DescriptionSodium- and chloride-dependent transporter xtrp2 (solute carrier family 6 member 18).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .The orphan transporters are an expanding group of putativetransporters that have been cloned.ut as yet have uncharacterisedsubstrate(s) for transport. They include NTT4 and NTT73.hich were clonedfrom rat brain tissues .nd a family of alternatively-spliced variantsfrom kidney . Sequence analysis strongly suggests that these indeed areNa+ and Cl- -coupled cell membrane transporters.ince they show significantidentity.nd similar predicted topology.o the functionally-characterisedmembers of this superfamily.
  IPR002438:Orphan neurotransmitter transporter
IPR000175:SNF 
Evalue:-228.795883178711 
Location:18-604
SequencesProtein: S6A18_HUMAN (628 aa)
mRNA: NM_182632
Local Annotation
Synapse Ontology
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05333
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter), member 18
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 95 residues, 1278469-1278752Exon2: 49 residues, 1285333-1285474Exon3: 48 residues, 1285865-1286003Exon4: 62 residues, 1288595-1288777Exon5: 39 residues, 1291064-1291175Exon6: 39 residues, 1292564-1292677Exon7: 45 residues, 1293645-1293774Exon8: 54 residues, 1295821-1295978Exon9: 70 residues, 1296669-1296874Exon10: 55 residues, 1297328-1297488Exon11: 55 residues, 1297722-1297882Exon12: 115 residues, 1298962-1299303Exon13: 2 residues, -Jump to S6A18_HUMAN  
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Loci Cluster (Details)Loci: 4703 713890-746421 ~-33K 28538(-)Loci: 4704 1103499-1165150 ~-62K 28551(SLC12A7)(-)Loci: 3442 1278469-1299303 ~-21K 28553(SLC6A18)(+)Loci: 4705 1445908-1498543 ~-53K 28561(SLC6A3)(-)Loci: 3441 271446-309792 ~-38K 28525(SDHA)(+)Link out to UCSC