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0S6A11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC6A11
DescriptionSodium- and chloride-dependent gaba transporter 3.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .
  IPR000175:Sodium:neurotransmitter symporter
InterPro domains unassigned to SynO:
Neurotransmitter transport systems are integral to the release.e-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters.hereby terminating their actions . Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+ and Cl-.n order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA).oradrenaline/adrenaline.opamine.erotonin.roline.lycine.holine.etaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters.hich are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+ and the counter-transport of K+.ith no apparent dependence on Cl- . In addition.oth of these transporter families are distinct from the vesicular neurotransmitter transporters . Sequence analysis of the Na+/Cl- neurotransmitter superfamily reveals that it can be divided into four subfamilies.hese being transporters for monoamines.he amino acids proline and glycine.ABA.nd a group of orphan transporters .GABA is the major inhibitory transmitter in the mammalian brain.nd iswidely distributed throughout the nervous system. Molecular cloningstudies have resulted in the cloning of three Na+ and Cl- -coupled GABAtransporters (known as GAT-1.AT-2.AT-3) and a betaine/GABA transporter(BGT-1). Each transporter shows varying affinities for GABA.ifferentsubstrate and blocker pharmacologies.nd different tissue localisation .Brain regions containing GAT-3 mRNA transcripts include the retina.lfactory bulb.ubfornical organ.ypothalamus.idline thalamus andbrainstem. GAT-3 mRNA was found to be absent from the neocortex andcerebellar cortex.nd very weak in the hippocampus . Furthermore.mmunocytological studies have demonstrated that this transporter may belocalised solely to glial (non-neuronal) cells.uggesting that glial GABAuptake may function to limit the spread of GABA from the synapse.s wellas to regulate overall GABA levels.
  IPR002982:GABA neurotransmitter transporter GAT-3
IPR000175:SNF 
Evalue:-1e+125 
Location:50-590IPR002982:GAT3TRNSPORT 
Evalue:0 
Location:593-605
SequencesProtein: S6A11_HUMAN (632 aa)
mRNA: NM_014229
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords,domains)
glia's reuptake of transmitter from synaptic cleft
sdb:0143 uptake by glia  (Evidence:keywords,domains)
reuptake of transmitter from synaptic cleft to presynaptic process.
sdb:0144 uptake by presynaptic process  (Evidence:keywords,domains)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05044
  Level 3 annotation:
    solute carrier family 6 (neurotransmitter transporter, GABA), member 11
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 97 residues, 10832916-10833206Exon2: 47 residues, 10836149-10836284Exon3: 49 residues, 10836396-10836537Exon4: 32 residues, 10839986-10840077Exon5: 46 residues, 10860898-10861031Exon6: 47 residues, 10891645-10891780Exon7: 36 residues, 10928774-10928878Exon8: 43 residues, 10935013-10935138Exon9: 39 residues, 10942689-10942802Exon10: 48 residues, 10945887-10946025Exon11: 36 residues, 10949836-10949939Exon12: 35 residues, 10950751-10950852Exon13: 59 residues, 10951714-10951885Exon14: 71 residues, 10954935-10955144Exon15: 2 residues, -Jump to S6A11_HUMAN  
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Loci Cluster (Details)Loci: 3333 11009455-11055934 ~-46K 25204(SLC6A1)(+)Loci: 3334 11269399-11279415 ~-10K 25205(HRH1)(+)Loci: 3332 10832916-10955144 ~-122K 25203(SLC6A11)(+)Link out to UCSC