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0S12A7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSolute carrier family 12 member 7 (electroneutral potassium-chloride cotransporter 4) (k-cl cotransporter 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0015379 chloride symporter activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
The K-Cl co-transporter (KCC) mediates the coupled movement of K+ and Cl-ions across the plasma membrane of many animal cells. This transport isinvolved in the regulatory volume decrease in response to cell swelling inred blood cells.nd has been proposed to play a role in the vectorialmovement of Cl- across kidney epithelia. The transport process involves onefor one electroneutral movement of K+ together with Cl-.nd.n allknown mammalian cells.he net movement is outward .In neurones.t appears to play a unique role in maintaining lowintracellular Cl-concentration.hich is required for the functioning of Cl-dependent fast synaptic inhibition.ediated by certain neurotransmitters.uch as gamma-aminobutyric acid (GABA) and glycine.Two isoforms of the K-Cl co-transporter have been described.ermed KCC1 andKCC2.ontaining 1085 and 1116 amino acids.espectively. They are bothpredicted to have 12 transmembrane (TM) regions in a central hydrophobicdomain.ogether with hydrophilic N- and C-termini that are likelycytoplasmic. Comparison of their sequences with those of otherion-transporting membrane proteins reveals that they are part of a newsuperfamily of cation-chloride co-transporters.hich includes the Na-Cl andNa-K-2Cl co-transporters. KCC1 is widely expressed in human tissues.hileKCC2 is expressed only in brain neurones.aking it likely that this is theisoform responsible for maintaining low Cl- concentration in neurones .
  IPR000076:K-Cl co-transporter
InterPro domains unassigned to SynO:
Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related . These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second transmembrane segment.This domain is found in a wide variety of permeases.s well as several hypothetical proteins.
  IPR004841:Amino acid permease-associated region
This is a family of K-Cl cotransporters. It includes bumetanide-sensitive sodium-(potassium)-chloride cotransporter.n electrically silent transporter system which is a mediator of sodium and chloride reabsorption. It plays a vital role in the regulation of ionic balance and cell volume. Bumetanide-sensitive sodium-(potassium)-chloride cotransporter belongs to the SLC12A family of transporters.
  IPR004842:Na-K-Cl cotransporter superfamily
SequencesProtein: S12A7_HUMAN (1083 aa)
mRNA: BC098390
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords,domains)
all kinds of ion channels that play their roles in the synaptic activity.
sdb:0308 ion channels and receptors  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 690 residues, 1103499-1105566Exon2: 46 residues, 1106463-1106597Exon3: 61 residues, 1110585-1110764Exon4: 38 residues, 1113458-1113566Exon5: 46 residues, 1116958-1117090Exon6: 58 residues, 1117197-1117367Exon7: 67 residues, 1118397-1118593Exon8: 58 residues, 1126747-1126916Exon9: 37 residues, 1127681-1127786Exon10: 42 residues, 1128485-1128605Exon11: 35 residues, 1129252-1129351Exon12: 41 residues, 1129808-1129927Exon13: 60 residues, 1130947-1131122Exon14: 21 residues, 1131815-1131873Exon15: 35 residues, 1132512-1132611Exon16: 58 residues, 1134691-1134859Exon17: 72 residues, 1136859-1137071Exon18: 82 residues, 1138346-1138588Exon19: 45 residues, 1140017-1140148Exon20: 20 residues, 1141420-1141475Exon21: 51 residues, 1142096-1142243Exon22: 43 residues, 1146647-1146770Exon23: 33 residues, 1147268-1147363Exon24: 58 residues, 1164982-1165150Exon25: 2 residues, -Jump to S12A7_HUMAN  
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Loci Cluster (Details)Loci: 4703 713890-746421 ~-33K 28538(-)Loci: 4704 1103499-1165150 ~-62K 28551(SLC12A7)(-)Loci: 3442 1278469-1299303 ~-21K 28553(SLC6A18)(+)Loci: 4705 1445908-1498543 ~-53K 28561(SLC6A3)(-)Loci: 3441 271446-309792 ~-38K 28525(SDHA)(+)Link out to UCSC